"Torasemide": litaelo ho sebelisoa. "Sandoz Torasemide": theko, sebaka, ulasan pelanggan

"Torasemide" - ea kajeno e matla diuretic lithethefatsi tseo ke phethahetseng bakeng phekolo ea nako e telele ea mafu a amanang le ponahalo ea edema. Ka lebaka la palo e nyenyane ea litla ea bongaka bohlokoa lehlakoreng, bophara ba e sebelisa ho phekola le ho feta. Ke sebaka se sireletsehileng ho diuretics tse ling sekgoqetsane le na le bopaki bo eketsehileng. Ka ho phekola mafu a sa tšoaneng litekanyetso li behoa e fetotsoeng. Hape, ho e sebetsa tabeng ea insufficiency tsa mosebetsi liphio esita le ka e tlase karaoke set lebelo glomeruli nephrons.

Litla "torasemide"

"Torasemide" ka moemeli sekgoqetsane (letsoai) sehlopha diuretics emelang luminal karolo ea epithelium tsa tubules tsa nephron ka nyoloha karolo e itseng ea sekgoqetsane la Henle. Ikitlaetsa le phello inhibitory ka lipalangoang-'moho le ions potassium le sodium chloride, ho haholo ho fokotsa bokgoni ba motlakase ya ka epithelium holim 'a nephron ena. Thibela likepe lebaka ke likhathatso tsa Ion lipalangoang sodium reabsorption tswa moroto mathomo, e leng eketsa diuresis.

Hoo e batlang e diuretics tsohle sekgoqetsane bakela meferefere electrolyte ka lebaka la le matla le tsusumetso e mpe reabsorption tsa ions potassium, sodium, magnesium le chloride le. "Torasemide" ka tekanyo e monyenyane ama tlhopho ya potassium le magnesium, ka lebaka la ho eo e ka tlaase haholo ditiragalo tsa arrhythmias, ho ipolaisa tlala, pipitlelano, bofokoli mesifa. Hape, lithethefatsi ho o fokolang fihlela moo ho na le masakana sebopeho sa thromboxane A2, extending lijana. O ile a boela o beha diboloko aldosterone receptors infarction, inhibiting le thulaganyo ya fibrosis tsa mesifa pelo.

ya litatoli na

Khomaretse moriana "Torasemide" taeo pukwanana na le boitsebiso bo mabapi le lefu, e leng o ile a sebelisa bakeng sa kalafo ya. "Torasemide" e bontša bakeng sa:

• pathogenetic kalafo ya ea bohlokoa kgatelelo ya madi manganga ho phekolo le tlhakantsuke ya inhibitors Ace (ARBs) thiazide diuretics;
• ho phekola hloleha foleng pelo, e amang ho potoloha ha mali didikadikwe overload;
• bontshang matshwao kalafo ya ho hloleha foleng renal, ho akarelletsa le filtara e ka lebelo tlaase (ka tlase ho 20 di ml \ mets);
• bontshang matshwao phekoloa sebete (ka hypoalbuminemia amanang) edema e le mefuta e meng ea ho "Furosemide".

Ha kgatelelo ya madi "Torasemide" analogues le generics sebelisoa feela ka mor'a ho hlōleha ha diuretics thiazide. lithethefatsi A ka tsamaisoa ke nako e telele ka lebaka la palo e fokolang ea litla ea bongaka bohlokoa le kotsi lehlakoreng ka hloleha renal. Bao e leng ba "torasemide" ka tlaase haholo ho feta hore ba "Furosemide".

Litaelo tsa tšebeliso

E thehiloeng melao e tataisang ea tleleniki bakeng sa lithethefatsi "Torasemide" taeo pukwanana kenyelletsa ditokiseletso litšobotsi tsa dosages ea lithethefatsi e hlokehang bakeng sa kalafo le khalemelo ea lefu lena le phofung. Moo lithethefatsi ka boeona e ke e fumaneha ka matlapa a nang le metsoako e latelang: 2,5, mg, 5, mg, 10 mg, ea lilemo li 20 mg,, 50 mg,, 100 mg,, 200 mg,.

Ho nka lithethefatsi ka letlapa hoseng, ho sa tsotellehe lijo. Bakeng sa tekanyetso tsena tsa moriana "Torasemide" theko e fapaneng: e ka tlaase ka lethal dose bonyane le phahameng ka ho fetisisa ho palo e kahodimodimo ea. Ho ea ka ya data karolelano, matlapa a 30 ea lithethefatsi e ho 5 mg, ba ka bang 400 li-ruble. Ha fumana lethal dose ena li aba ka mokgwa o latelang ho latela matšoao a reng:

• ea ho phekola sa kgatelelo ya madi nkiloeng 2,5 - 10 mg, / ka letsatsi;
• o ile a fumana 10-20 mg, / ka letsatsi a ho hloleha foleng pelo;
• foleng renal ho hloleha - 50 mg, kapa ho feta;
• sebete hloleha hloka liphetoho lethal dose ka bomong.

Lehlakoreng Liphello "torasemide"

Khomaretse moriana "Torasemide" taeo pukwanana na le boitsebiso bo mabapi le litla multiple lehlakoreng. Ka lethal dose phekolo, ke hore, ho fihlela ho 200 mg, ka letsatsi ho eketsa kotsi ea mathata thromboembolic, cardiac ischemia, bokong. Ho eketsa kotsi ea e fetang litlhaselo tsa ischemic le myocardial infarction, embolism methapo, arrhythmias. Ho na le boetse ho na le kgonego ya ketsahalo ea rashes alejiki kapa hives ha mokuli a se predisposition.

"Torasemide" ka linako tse ling ho etsa hore ho nyekelwa ke pelo kapa ho hlatsa, ka seoelo kena dipakeng tsa ho dyspepsia, letšollo. O ile a hlalosa Maemong a ka thōko sa pancreatitis nakong kalafo le "torasemide". Hape e ile ea eketseha transaminases e amanang le sebete, e leng se bontšang sebete toxicity ea lithethefatsi tekanyetso e phahameng. Ka linako tse ling bakuli ba tšoenyehile ka ringing litsebeng ea, pono thothofatsang.

Ha u fumana lethal dose nang le chefo e ho ntshetsa pele boemo ba overdose le matšoao a hanyane. Overdose e tsamaea le felloa ke mokelikeli ka moroto wa: diuresis telele le khafetsa, a ka hlahisa hypotension, vascular putlama, fainting, setorouku, ischemia bokong ka morao.

Contraindications le mefokolo ea kopo

Lithethefatsi "Torasemide" analogues le lithethefatsi karela ke ke sebediswa ka ho ba teng ha contraindications feletseng. Tsena ke alejiki itsoara joang ho lithethefatsi kapa binders. "Torasemide" thibetsoe ho sebelisa ka ho hloleha renal le anuria, sebete ho hloleha ha ka boemo ba coma e amanang le sebete, le tachyarrhythmias. Contraindicated noa nakong diabolololo le ea bokhachane, e le hammoho le ka tlaase ho lilemo tsa lilemo tse 18, hypersensitivity ho sulfonamides.

Lehlakoreng le litla kopantswe "torasemide"

Ka ho phekola kgatelelo ya madi lipilisi "Torasemide" ka ba le phello e mpe ka tsela ea gout. Ho tloha tubules proximal tsa nephron a sebetsang a ntho ingested ke lipalangoang mafolofolo, ho na le tlhōlisano thibelo ea excretion ea acid e uric. Khahlanong le semelo sa tshebediso ya "torasemide" phahameng kgonego ya hyperuricemia le a hlobaetsang le gout.

Moriana o "Torasemide" e tšoauoa ka ketso e itseng ka karolo proximal tsa tubular epithelium sekgoqetsane la Henle. Ka lebaka la ho matla diuretic e le hantle le electrolyte imbalance ena e etsa hore monyetla oa ditshebeditsano ea bongaka bohlokoa diokobatsi. Ba kotsi, e seng oa bohlokoa 'me tse lakatsehang. Har'a kotsi le bohlokoa ke ena:

• phahameng lethal dose (50 mg, / ka letsatsi a) "torasemide" ha sebelisoa hammoho le litokisetso tsa polatinamo kgothaletsa e toxicity ea bobeli;
• tekanyetso kgolo "torasemide" (50 mg, / ka letsatsi a) eketsa litla nephrotoxic le ototoxic ea lithibela-mafu aminoglycoside;
• ka lithibela-mafu cephalosporin, ha sebelisoa hammoho le "torasemide" ka lethal dose ea la 50 mg, / ka letsatsi a bonahala thepa nephrotoxicity;
• salicylates hammoho "torasemide" (50 mg, / ka letsatsi a) tšoauoa neurotoxicity.
• "Torasemide" khahlanong le semelo sa ka hypokalemia a lekanyelitsoeng eketsa susceptibility tsa myocardium ho glycosides cardiac, eketsa inotropic bona le phello antiarrhythmic, ho eketsa kotsi ya toxicity;
• kotsi ea hypokalemia e ile ea eketseha ka pataganeng tšebeliso "torasemide" le corticosteroids kapa letsoai laxatives;
• "Torasemide" kgothaletsa phello ea "theophylline" curariform le mesifa relaxants.

Lakatsa liphello tsa tšebeliso hlakanywa

Tsa litla a lakatsa hore hlokang go baya leitlho, e ea fokotseha ka khatello ea mali nakong ea kalafo le Ace inhibitors. "Torasemide" ka lebaka la ho tlosoa ha mokelikeli ho fokotsa khatello ea hydrostatic ea mali le ho kena dipakeng tsa ho lerotholi ka khatello ea mali. karolo ena ke ea bohlokoa ka ho phekola kgatelelo ya madi le hloka khalemelo ea lethal dose ea Ace inhibitors. Ho feta moo, ea ho phekola ba phekolo manganga kgatelelo ya madi le motswako wa e Ace sesitisa "torasemide" re lumella hore re fihlella tlwaelegileng a ea khatello ea mali ka 90% ea bakuli.

Ea ho phekola ba ho hloleha foleng pelo ke ea bongaka bohlokoa phello ea fokotsa vasoconstrictor mosebetsi oa catecholamines. Pelo ea ka e le semelo sa diuretic phekolo "torasemide" fokolang sa arabele ho stimulatory matšoao adrenaline le noradrenaline. Leha ho le joalo, phello e tšoanang ba ho fokotsa ho atleha ha epinephrine le norepinephrine nakong resuscitation.

litla mpe tsa sebelisana le

Ho na le litla bohlokwa ba tsamaiso thibelo ha ho kopantswe le dintho tse itseng. Ka ho khetheha:

• litokisetso tsa sequestrants bile acid e fokotsa nkhape "torasemide" ea mantle a, fokolisa phello ea e qetellang;
• analgesics narcotic (NSAIDS) fokotsa ho atleha ha "torasemide";
• "Probenecid" ka lebaka la ho dithulaganyo kholiso urikozuricheskih thibela khetha "torasemide" ka lumen tsa tubules e, fokotsa katleho ea eona.

litšobotsi tse bapisang "torasemide"

Ka ho lokisetsa "Torasemide" analogs ka tlelaseng, kinetic le generics. Har'a sehlopha sa emeloa analogues: "Furosemide", "bumetanide," "acid e ethacrynic". Ha ho bapisoa le "Furosemide" "Torasemide" e tšoauoa ka sa qala ho lieha ya bohato le le phello e feta nako e telele correlated le eketseha diuresis. Ho fana ka e le hantle diuretic ke hoo e ka bang ka matla a tšoanang e le hore ba "Furosemide" "Torasemide" e na le liphello tse fokolang lehlakoreng amanang le ka potlako electrolyte imbalance.

"Bumetanide" e tšoauoa ka e matla le ho feta diuretic thepa hore e amahanngoa le liphello tse ngata-morao. asiti Ethacrynic na le ka tlaase ho qala sekhahla diuretic e le hantle le se ke ka seoelo sebediswa lithethefatsi. The pharmacokinetics ea lithethefatsi "Torasemide" lekodisisa ditsebi hlokomela ntlha e 'ngoe ea bohlokoa. Lithethefatsi na thepa ea "boea sekoele": diuresis mora kholiso ke tekatekanyo sodium na compensatory tshegetsa le go tlotla lona.

Pharmacokinetic analogues "torasemide"

The "Torasemide" litlhare tataiso e fana ka tlhahisoleseding e mabapi le kopo ea eona bakuli ba ea bohlokoa kgatelelo ya madi. Hammoho le ea lithethefatsi, bakeng sa kalafo ya kgatelelo ya madi le ba a boela a sebelisa diuretics thiazide, potassium-o qenehela. Le thiazide loketseng butle tlang le ka nako e telele diuretic e le hantle ke lithethefatsi tsa ho etsa khetho.

Mabapi le tsena pharmacokinetic likarolo analogues ya ba lokisetsa ho "Torasemide" kopo ka 'na ba tse latelang: ho phekola kgatelelo ya madi, manganga ho phekolo tekanyetso le tlhakantsuke Ace sesitisa (kapa angiotensin receptor blocker) le thiazide ka. Hape, "Torasemide" le sebelisitsoe ka foleng renal ho hloleha kalafo ena le bokhoni fokoletse theko karaoke set.

Generics "torasemide"

Ka ho lokisetsa "Torasemide" pukwanana amohele taeo, analogues, ho bonahala le ho contraindications botlalo khethollang phello ea oona ka sehloohong - eketseha diuresis. Ho feta moo, ketso joalo o na le lithethefatsi pele le karela. Ea bobeli e na le palo e tšoanang oa "torasemide", empa hlahiswa tlas'a mabitso a mang cha.

The tummeng ka ho fetisisa ke ena: "Britomar", "Diuver", "Sandoz Torasemide", "Trifas", "Torcida", "Trigrim". Nakong ea liteko e pharaletseng ea mahlahana diokobatsi se tšoane bohlokoa li ne li hlokomela pakeng tsa bona ka ho Russia. E mong le e ba formulations ka holimo nka sebaka ka botlalo le 'ngoe ea bona.

likarolo tse moruo kalafo "torasemide"

Ka ho phekola kgatelelo ya madi ha diuretics thiazide na thuso hammoho le inhibitors Ace (kapa ARBs), ka laolwa kalafo lithethefatsi "Torasemide": litaelo bakeng sa ho sebelisoa pheha khang lethal dose le 'ngoe motšehare. Litšenyehelo tsa khoeli le khoeli tsa kalafo e ka bang 400 li-ruble ka theko ea matlapa a 60 ea lithethefatsi ka 760-800 li-ruble. Bakeng sa papiso, theko ea khoeli le khoeli ea phekolo "Furosemide" seoelo feta 20 li-ruble. Empa ea bobeli bakeng sa kalafo e tswelang pele ea kgatelelo ya madi ke tsa tšebeliso e nyenyane.

Ka ho hloleha foleng pelo le edema ea ba theko ajoa didikadikwe ea khoeli kalafo "Furosemide" e ka 20-30 li-ruble. Ka ho lokisetsa "Torasemide" theko ke makhetlo a 10-15 le ho feta. Ea bobeli e na le phello e le bonolo, ke hore bonahaleng eketsa excretion ea moroto ka lihora tse pele ba ea moketeng oa lijo. The "Furosemide" litšobotsi tsa etsolla: ho eketsa haholo palo ya moroto ka lihora tse peli pele le felloe ke butle-butle tsa khumo moroto.

Ka lebaka leo, bakuli ba employable le kgatelelo ya madi kapa foleng renal insufficiency kapa ho potoloha ha mali ho utloahalang sebetsa "Torasemide" thuto (theko lona o ile a bontša ka holimo) ka kopo e nang le boitsebiso bo mabapi le ho ntlafatswa bohlokoa tsa diuresis ka lekhetlo la pele ba baeti ba fihlelang ho. Leha ho le joalo, le tlohela mosebetsi lilemo tsa bakuli ho ba sieo ha bohlokoa ba ho kena mosebetsing, moroto khumo lebelo ke hoo e ka bang irrelevant. Ha aa ka a bōpa le mathata, 'me ka hona lumella u ho fumana e le theko e sehlopha sa manaka - "Furosemide".