"Kaffetin Cold": litaelo bakeng sa ho sebelisoa, sebopeho, analogues

ke pheko "Kaffetin Cold" ke efe? Ea ho hlophisoa le lintho tse khethollang moriana tla tšohloa mona ka tlase. Re boetse re u bolella mabapi le kamoo ho ka fumana itse moriana o le ho se mafu a eona e hlophisitsweng.

Sebopeho, ambalaji, sebopeho

The moriana o "Kaffetin Cold" e marketed foromo Letlapa le biconvex oblong sebopeho (a mola ka lehlakoreng le leng) a tlotsitsoeng a maputsoa filimi-a tlotsitsoeng. Ba behoa ka blister perforated, e bopilweng ka aluminium foil le tse tharo-lera sebeletsang pepeneneng filimi, e leng ka lebokose lebokose.

Hore e na le moriana e le "Kaffetin Cold"? Sebopeho sa lithethefatsi ena ke:

• dextromethorphan hydrobromide (15 mg,);
• pseudoephedrine hydrochloride (30 mg,);
• ascorbic acid e (60-62 mg,) ka granulate, e leng e na le 97% oa vithamine ea C, 'me 3% hydroxypropyl methylcellulose;
• paracetamol (500-555 mg,) ka mokgwa wa granules entsoeng ka 90% ea ntho e, hammoho le dikarolo ea thusang ka prozhelatinizirovanogo starch, acid e stearic le povidone.

E lokela ho ile a hlokomela hore "Kaffetin Cold" ka metsoako eketsehileng kenyeletsa magnesium stearate, silica colloid, microcellulose, croscarmellose sodium le talc.

Filimi barbotage ea moriana o le e entsoe ka putsoa dae, macrogol, thaethaniamo dioxide, polyvinyl joala le talc.

The pharmacology ya moriana

thepa life bath ea matlapa a 'Kaffetin Cold "? Thupelo ea bolela hore sesebelisoa ke kgona ho bontsha analgesic le thepa antitussive.

The mochine ea nkang khato ea moriana o le ka lebaka la ho ba teng ho eona ea likarolo tse ka holimo. Tšohla lintlha tsa bona hona joale:

• Paracetamol ama 'mele le obezbolivayusche zharoponizhayusche. elements ena ke khona ho thibela Cox ka CNS. Hlahellang ka litla ka ho toba le litsi bohloko le thermoregulation.

The tšobotsi khethollang ea motsoako ona NSAIDs ke kakaretso ea ho hloka e le hantle-ba khahlanong le a hlabang. Paracetamol ha halefisa pampitšana tshilong ya dijo le ha e ame ho metabolism metsi le letsoai, e le ha ho hlonamisitsoe ama tswakana tsa prostaglandins ka lisele pheriferale.

• Ke eng hape e ke ka tsela e hlollang ea lithethefatsi "Kaffetin Cold"? Tse qotsitsoeng pseudoephedrine o khona ho fana ka tshusumetso tapered likepeng tse ka mucosa ba pharynx le nasal cavity. Hape, elements ena haholo ho fokotsa ho ruruha, 'me kahoo fokotsa secretion ka nasopharynx ho le bonolo nasal hema.
• asiti Ascorbic e leng ka koloi, ba hlaphoheloa oa vithamine ea C khaello, eo e atisa ho a hlokomela nakong eo sefuba.
• Dextromethorphan ama setsi sa khohlela. Ho fokotsa ho tiea tsa khohlela ommeng e amanang le ho teneha a nasopharynx mucous bakeng sa sefuba.

thepa kinetic

Joang absorption ea lithethefatsi "Kaffetin Cold"? Reviews ditsebi bontša hore absorption ea boholo ba paracetamol sa le hlaha ka intestine nyenyane. Ka tsela eo tsa mahloriso tsa lona phahameng ka ho fetisisa le lero la mali le hore mali a ile a re ka hare ho metsotso 30-90 ka mor'a tsamaiso molomo.

The metabolism tsa ntho ka potso (ka 90-95%) le hlaha ka sebete. Ka lebaka leo, derivatives khathetseng moeeng ba thehoa (ka lebaka la conjugation itsoara joang ka acid e glucuronic le sulfates). Ba ka ba le phello thibela tsamaisong ea potlakisang tsebetso ea lik'hemik'hale sebeteng, hammoho le ho qholotsa lefu la liseleng.

The halofo bophelo ba karolo e tsoang ho batho e lihora tse 1-4. Di behilwe paracetamol le metabolites lona ke liphio. Ka botsofali ka 'na ba ea fokotseha ka rengwa moriana, hammoho le ho eketseha ha nako halofo bophelo.

Mora dextromethorphan kena 'meleng oa motho, o hoo e batlang e hang-hang kena maling. Ea mahloriso phahameng ka ho fetisisa ya elements sena lero la mali e ketekoa ka mor'a metsotso e 130 ka mor'a ho nka matlapa a. ntho ena e metabolized ka sebete. metabolites lona di excreted ka moroto wa.

Pseudoephedrine hape ka potlako ananelang ka systemic ajoa ka mor'a tsamaiso molomo. Ea mahloriso phahameng ka ho fetisisa ea ntho e fihlellwa ka mor'a ka 2 lihora tse lero la mali. Halofo ea bophelo ba pseudoephedrine ke ka 6 lihora. E metabolized ka sebete (karolo e itseng), ka tsela eo eaba ba etsa sehlahisoa eo o ile excreted ka moroto wa.

Ha e le asiti le ascorbic, e hantle ananelang pampitšaneng gastrointestinal le ka potlako abeloa lisele tsohle. karolo ena e reversibly oxidized ho degidroksiaskorbinovoy acid e. Tabeng ena ba bang ba ka vithamine C amohetsweng ke 'mele, metabolized ka elements bitsoa ascorbate-2-sulfate.

Excreted ntho e bonahala ka moroto wa.

ya litatoli na

Lithethefatsi "Kaffetin Cold" e sebediswa bakeng sa kalafo bontshang matshwao ya ntaramane le sefuba, ho akarelletsa le ketsahalo e sa matšoao ao a sa thabiseng, tse kang hlooho e opang, khohlela o omileng, bohloko mesifa, bohloko metso ea, nko runny, feberu, sinuses nasal le nko .

Contraindications

Lithethefatsi "Kaffetin Cold" a ke ke a sebelisoa ho bakuli ba maemo a latelang:

• bokhachane;
• Hypersensitivity ho moriana;
• congenital kgaello ya tsoekere-6-phosphate dehydrogenase;
• kgatelelo ya madi, gogoga lefu la pelo, angina pectoris;
• mafu a matla ka a liphio le sebete, lefu la sebete;
• tsoa hong baeti ba fihlelang ho ea antidepressants, inhibitors monoamine dihydrobenzophenanthridine le lithethefatsi tse sebelisoang ka ho phekola antiparkinsonian;
• diabolololo;
• lilemo lilemo tse 12.

Tlhokomeliso e moriana khothalletsoang hore:

• arrhythmia;
• nang kotsi hyperbilirubinemia;
• hyperthyroidism;
• bongata ba kokwanahloko lefu la sebete;
• hyperplasia tsa tšoelesa ea senya tšoelesa;
• lemalla joala;
• lefu la tsoekere mellitus;
• obstructive methapo lefu le sa foleng tlhaho;
• bronchial asma;
• mokhathala.

Moriana o "Kaffetin Cold": litaelo tsa tšebeliso

Ho nkoa feela e bolela ne a rerile hore tsamaiso molomo.

Litekanyetso li behoa bakeng sa batho ba baholo le bacha tloha ka ba lilemo li 12 ke 1 Letlapa ka makhetlo a mane ka letsatsi. Ka nako e le e lumelloa ho sebelisa e seng ho feta matlapa 2.

Nako e karohano pakeng tsa ea e sebelisang meriana ea lokela ho ba ka tlase ho lihora tse 4. Kahoo litekanyetso li behoa ea letsatsi le letsatsi ea lithethefatsi ha ea lokela ho feta matlapa 8.

Haeba ho na le feberu bakeng sa matsatsi a fetang 3 mora qalo ea phekolo, 'me e le khohlela omileng phehella bakeng sa matsatsi a 5, joale u lokela ho hang-hang ho batla thuso ea lingaka.

lehlakoreng liketsahalo

liphetoho e bohloko ka mor'a ho nka lithethefatsi ka eona e ka bontša ka litsela tse ngata, ho tloha hoo e ka bang tsohle makala le tsamaiso ea 'mele:

• ho nyekoa ke pelo, e omeletseng molomo, epigastric bohloko;
• somnolence, pherekano, teneha, ho tsekela;
• allergy ka pruritus, rashes letlalo, angioedema, urticaria;
• eketseha khatello ea mali, tachycardia ntshetsopeleng;
• khaello ea mali, thrombocytopenia, agranulocytosis, pancytopenia;
• nephrotoxic e le hantle, e leng e bontšoa colic renal, ntshetsopele ya necrosis papillary kapa interstitial nephritis.

E overdose ea meriana

Ka tekanyetso e phahameng ea lithethefatsi, mokuli a ka ba le ho nyekeloa ke pelo, tinnitus le bohloko sebakeng sena mala. Hape le ka lithethefatsi feteletseng dosages letlalo mokuli e ba lerootho, ho phahama le ho mofufutso fetoha palpitations khafetsa.

O ile a hlalosa hloka hang-hang e phallang mala. Hape, lethal dose ya laolwa ho ba le mamello butswe k'habone, tshwanelanang mamello boima. Haeba hlokahala, e bontshang matshwao phekolo.

sebelisana

Paracetamol ka tekanyetso e phahameng ho eketsa liphello tsa anticoagulants.

Tšebeliso ea lithethefatsi tse inducers tsa microsomal ho kena moea (mohlala, "Phenytoin", ethanol, barbiturates, "Rifampicin", "phenylbutazone", tricyclic antidepressants), le mahlahana hepatotoxic haholo eketsa sebopeho sa motho ea mafolofolo hydroxylated lihlahisoa tshilong ya dijo tsa paracetamol, e leng eketsa monyetla oa Development matla botahoa , ho kenyelletswa le baeti ba fihlelang ho ya tekanyetso e nyenyane ea lithethefatsi.

sebelisoa ka nako e telele ya barbiturates fokotsa bokgoni ba ho paracetamol.

Ha e kopana le paracetamol le salicylates eketsa kotsi ea ho tšoaroa ke kankere ea senya kapa liphio.

sebelisoa ka nako e telele ya NSAID le paracetamol khothalletsa ketsahalo analgesic nephropathy, renal papillary necrosis le haholo haufi-ufi qetellong-sethaleng renal ho hloleha.

Sebelisa "diflunisal" isang phello hepatotoxic ya moriana.

Melato e tshebediso ya pseudoephedrine le mahlahana a mang sympathomimetic ka 'na kenya letsoho hore ho le ketsahalo e sa litla nang le chefo e,' me na le phello e tseloe. Ha e kopana le karolo ena le inhibitors monoamine dihydrobenzophenanthridine hangata e isang ntshetsopele ya bothata hypertension. Tabeng ena, ho sebelisa lithethefatsi ka eona ba lumelloa ho na pele ho moo ho feta matsatsi a 14 ka mor'a ho amohela monoamine dihydrobenzophenanthridine inhibitors e se e fediswa.

Melato e sebelisoa ha "Propranolol" kgothaletsa ho pressor e le hantle hore ke pseudoephedrine. Ho feta moo, ha u sebelisa e qetellang ka fokotswa le phello hypotensive tsa lisebelisoa tse kang "methyldopa", "reserpine", "mecamylamine" le sa t. N.

lintlha tse hlakileng

Hona joale u tseba hore ena ke lithethefatsi e le "Kaffetin Cold."

Methamphetamine - ke methamphetamine. Ke stimulant le etsa hore ho itšetleha phahameng mabapi le seo e amanang le lithethefatsi. Batho ba bang ba leka ho tlisa ena karolo ya ea lithethefatsi "Kaffetin Cold." Sekgala ea lithethefatsi hlahiswa ka litsela tse fapaneng. baeti ba fihlelang ho ea hae e etsa hore nyakallo 'me kahoo hampe ama tsamaiso ea tsohle le makala.

Nakong ea kalafo, lithethefatsi le lokela ho nkoa e ho hlokahala hore ho hlokomela boemo tshebetso sebeteng mokuli, hammoho le litsupa mali pheriferale.

Ho pholletsa le kalafo mokuli e thibetsoe ho noa lino tse tahang, kaha sena se ka etsa hore hepatotoxicity ketso ea lithethefatsi. E tšoanang tsoela bakeng sa lisebelisoa caffeine le lihlahisoa.

O ne a nka moriana o le tšusumetso e ka ho toba le le matla a mokuli ho khanna ka har'a sephethephethe le ho kopanela mesebetsing e meng leha e le tse hlokang hore mahloriso phahameng hloko.

Lithethefatsi "Kaffetin Cold": siea ho tswa bapharmasi

Ka lebaka la 'nete ea hore meriana ena e atisa ho sebelisoa e le sethethefatsi se ka, ho lokolloa feela holim' a nehelano ea lengolo la ngaka le ngaka. Ka tsela eo, ho fumana e joalo e lithethefatsi bapharmasi ke ho le thata haholo. Hangata ho e buuoa ka mor'a ea pele ho odara.

lithethefatsi tšoanang

Ho na le ho bolela tse ngata tseo ka tsona lithethefatsi ka potso e ka nkeloa sebaka. Ka ho fetisisa ratoa kenyeletsa tse latelang: "Amitsitron Forte", "Antigrippin", "Bol-matha Premium", "Vokasept", "Gripgo", "Gripkold-N", "Gripotsitron Forte", "Gripflyu", "Dolar", " batang H "," Koldreks "," Koldfri "," Lemsip Lemon "," Novalgin "" Panadol eketsehileng "," Rinzai "," Tamipul "," Farmatsitron "le ba bang.