Lithethefatsi "Doxorubicin": taeo e pukwanana, recensioni, foto, foromo lokolloa, litekanyetso li behoa, polokelo. "Doxorubicin-Lance": litaelo tsa tšebeliso

Kankere e kotsi haholo ho bophelo ba motho. Ho na le kotsi ebile ha ba laolehe lisele tse proliferating, tse khonang ho phunyeletse ka dinama tse nyenyane tse e potolohileng 'me metastasize ho makala tse ling.

Ntshetsopeleng ya lithethefatsi le mekhoa ea phekolo e bakeng sa mafu a joalo ke mosebetsi oa bohlokoa. Ka bomalimabe, ho fihlela joale ha ho motho ho fihlela qetellong 'me ha kea etsa qeto ea. Leha ho na le ba ntse ba lithethefatsi e ka fokotsa karohano ea lisele hlahala. E mong oa bona o ile a bua meriana "Doxorubicin". Litaelo bakeng sa ho sebelisoa le photo photo photo photo ea lithethefatsi li tla koahela sehloohong sena. Ho eona u tla fumana boitsebiso bo mabapi le kamoo ho boloka itse ho bolela oo theha e fumaneha bakeng sa ho sale, le tse ling.

Ambalaji, sebopeho, sebopeho le tlhaloso

Foromo seo e rekiswa "Doxorubicin"? Litaelo bakeng sa ho sebelisoa bontša mefuta e latelang ya sehlahiswa:

• Lyophilizate bakeng sa ba lokisetsa ho ea tharollo bakeng sa intravascular le intravesical ente. Ke khubelu bosehla porous boima 'me e na le ntho e le mafolo-folo tse kang doxorubicin hydrochloride. metsoako e le tlatsetso sebelisa mannitol. Meriana e rekiswa ka libotlolo, kenyeleditsweng ka lebokose lebokoso.
• Ho tsepamisa mohopolo bakeng sa ho hlahisa tharollo bakeng sa intravascular le intravesical ente. Ke mokelikeli khubelu le e bonaletsang e nang doxorubicin hydrochloride le e fumaneha ka libotlolong 'me mabokose.

The pharmacology ya moriana

Ke moriana ena e le "Doxorubicin" ke efe? Litaelo tsa (mofuta o lokolloa ha lithethefatsi ile a bontša ka holimo) tšebeliso e tlaleha hore e le e-ba khahlanong le hlahala anthracycline lithibela-mafu, e neng e ka thōko ho tloha litso tsa fungus e Streptomyces peucetius. O khona ho fana ka litla antimitotic le antiproliferative.

Sebelisana le DNA, e moriana o thibela RNA polymerase, DNA polymerase le topoisomerase mofuta 2, 'me hape activates tlhahiso ea radicals mahala le sebetsang sebakeng sa hae ka leboteng ka seleng. Ka lebaka la tshusumetso joalo, ae fokotsang lebelo DNA boikatiso le tsa likokoana-hloko nucleic acid e tswakana.

Ho ke ke ha khoneha a se ke a ela hloko taba ea hore re hlahlobisise mokhoa oa o na le ka ho toba cytotoxic sebediswa. lisele tsa bontša ka nahanela ho khetheha ho lithethefatsi ka G2-mohato le S-mohato oa bophelo ba bona.

thepa kinetic

entsprechen seo kinetic tlholeho ka lithethefatsi "Doxorubicin"? Litaelo bakeng sa ho sebelisoa e bolela hore ka mor'a ente intravenous, sesebelisoa sa kamehla aba multiphase. Nakong ea pele metsotso e 5 ea moriana o ka potlako haptjoa lisele, 'me mahloriso lona ka mali decreases ka potlako. Ha e le mohato oa bobeli, e phethahatsoa limolek'hule lithethefatsi lieha ho tloha lisele ka.

Concentrates mafolofolo nakong ea lithethefatsi ka sebete, phenya liphio, spleen, matšoafo le myocardium. E boetse e le kenella ka hare ho placenta le e excreted le lebese.

Arabela liprotheine lero la mali le hlaha ka 75%. Metabolism ea lithethefatsi ka sebete, ka tsela eo eaba ba etsa le sehlahisoa a sebetsang a kang doxorubicinol.

Nakong phokotsong ea radicals mahala tswakana potlakisang tsebetso ea lik'hemik'hale ho ka ama ntshetsopele ya toxicity cardiac.

Halofo ea bophelo ba doxorubicin le doxorubicinol tshwanang le e ka 20-48 lihora.

Hoo e ka bang 40% ea lethal dose ea lithethefatsi o lokolloa hammoho bile, 'me% 6-11 feela ea doxorubicin le derivatives sa eona, kaha matsatsi a 5 a fumanoa ka moroto.

ho bonahala

lithethefatsi "Doxorubicin" ka thonngwa ke seo mafu?

Litaelo bakeng sa ho sebelisoa (kankere ea senya ke sesebelisoa sa sebelisoa hangata haholo) e bolela hore moriana o etsa hantle ha:

• thyroid tsoelesa kankere, sarcoma Kaposi le Ewing;
• Wilms 'hlahala, gastric kankere, seleng e nyenyane foromo ya kankere ea matšoafo;
• insulinoma, kankere ea matsoele, diagnosis;
• esophageal kankere, carcinoid, neuroblastoma;
• osteogenic sarcoma, mathomo hepatocellular carcinoma, bao e seng Hodgkin o lymphoma ;
• Bakeng sa kankere ea tšoelesa ea senya tšoelesa, kankere ya hlooho le molala 'me a bolaeang ho thymoma;
• bakeng sa kankere cervical, mefuta e meng ea dihlahala lekwalata;
• uterine sarcoma, endometrial kankere, lefu la Hodgkin ya;
• rhabdomyosarcoma, a hlobaetsang le kankere ea mali;
• foleng lymphocytic kankere ea mali, multiple myeloma.

Contraindications

Seo ke boemo ba mokuli qosang hanela mo lithethefatsi "Doxorubicin"? Litaelo tsa tšebeliso, oncologists oa sebele re sesebelisoa sa ipaka se e atlehang haholo ka se:

• sensitization ho doxorubicin kapa lintho tse ling tse lithethefatsi, hammoho le baemeli ba anthracyclines le anthracenediones;
• phekolo pele, kapa litho tse ling tsa anthracenediones anthracycline ka fokotsa tekanyetso, hammoho le ho hloleha sebete (haholo), myocardial infarction, arrhythmias, tšoaetso a hlobaetsang le bongata ba kokwanahloko le ha pelo (bakeng sa tsamaiso intravenous);
• lihlahala tse kotsi, hlaha hoa ka lerako la senya, mosese pampitšana tšoaetso ea le cystitis (bakeng sa intravesical).

Ba hlokolosi a feteletseng, lithethefatsi ena lokela ho sebelisoa bakeng sa batho ba ileng ba amohela matla a etsoa chemotherapy, hammoho le mabaka a kotsing ea ho cardiotoxicity, tlōlo ea sebete, lesapo moko khukhuneloa ea lisele kankere le botenya.

Ho phaella moo, ka hloko nkoa e le ea lithethefatsi e hlophisitsweng bakeng sa bana le batho ba lilemong tsa ho e tsoetseng pele, 'me e le karolo ea selotlolo mefuta le multicomponent antitumor phekolo.

Lithethefatsi "Doxorubicin": litaelo bakeng sa ho sebelisoa, litekanyetso li behoa

Ho ea ka litaelo tseo, nahana ka lithethefatsi ka laolwa intraarterially, entoe le intravesically. Ho lokela ho hlokomeloe hore thulusi ena e tla sebelisoa singly kapa hammoho le lithethefatsi tse ling tse cytostatic ka dosages fapaneng.

Reconstituted lithethefatsi tharollo "Doxorubicin" ke ho sebediswa hang-hang ka mor'a proizvodnje lona.

Intravenous paakanyong ente

Ka litekanyetso li behoa kgothaletswa ba monotherapy "Doxorubicin" ka potoloho e 60-75 mg, / sq. m mong le e mong libeke tse tharo. Ka tloaelo ho, ea lithethefatsi e tshelwa hang. Leha ho le joalo, lethal dose ena e ka tsamaisoa le bakeng sa liente tse ngata (ka chelete ea 25-30 mg, / sq. M ka letsatsi la pele matsatsi a 3 ea potoloho e).

Ho fokotsa e le hantle chefo ea mokhoa sebediswa tsamaiso ea beke le beke ea 10-20 mg, / sq. limithara makhetlo a beke.

Ha ho kopantswe le mahlahana a mang anticancer a sebetsang a moriana o laolwa ka litekanyetso li behoa potoloho ka palo ya 30-60 mg, / sq. m mong le e mong libeke tse 4.

dithuto khafetsa kalafo etsoa feela ka mor'a hore ho tlosoa ha matšoao a kaofela ha toxicity.

The lethal dose kakaretso ea lithethefatsi ha ea lokela ho ba ho feta 550 mg, / sq. m.

Intra-ea bohlokoa tsamaiso ea moemeli oa

Kamoo ke ente intra-ea bohlokoa "Doxorubicin" lithethefatsi? Tataisa e bolela hore ho fana ka sidetone batho ba nang le hepatocellular carcinoma a sebetsang a moriana o o laolwa ho mothapo tloaelehile hore batho ba e amanang le sebete ka litekanyetso li behoa ea 35-150 mg, / sq. m. Ka dikgao nako e tšoanang pakeng tsa lipotoloho tse lokela ho lekana ho tloha libeke tse 3 ho likhoeli tse 3.

Ho qaloa ho moriana ka senya

Ka senya tshelwa lithethefatsi "Doxorubicin-Teva"? Litaelo bakeng sa ho sebelisoa e tlaleha hore litekanyetso li behoa sena se bolela bakeng sa tsamaiso intravesical e lokela ho ba 35-50 mg, ka ho ya ka tlhomamiso.

mekgwa ya tshebetso ya kalafi lokela ho phethahatsoa ka dikgao ya matsatsi a 7-28, ho itšetlehile ka ka morero (thibelo kapa kalafo).

Mahloriso tsa tharollo ea lithethefatsi lokela ho ba 1 mg, / 1 tharollo ml tse metsi kapa 'meleng.

Instillation o etsoa ka hare ho lihora tse 2. Qetellong ea mokuli lokela feela senya.

litla-morao

Ho lokisetsa "Doxorubicin", eo thupelong e hlalositsoeng ka holimo e ka etsa hore liphetoho tse latelang lehlakoreng:

• ho hlatsa, ho bohloko mpeng, ho nyekoa ke pelo, colitis, stomatitis, letšollo, esophagitis, molomo mucosa hyperpigmentation, ho ipolaisa tlala, e ile ea eketseha bilirubin mahloriso maling, gastrointestinal mali, e ile ea eketseha transaminases e amanang le sebete;
• lethal dose-itšetlehileng ka reversible leukopenia, thrombocytopenia, khaello ea mali, leukopenia, neutropenia;
• sinus tachycardia, atrioventricular le literata, tachyarrhythmia foromo congestive ha pelo, bradycardia, thrombophlebitis, ea lekala le literata Hae sosobaneng, tsela e sa tloaelehang ka ECG, ventricular arrythmia, embolism methapo, phlebitis, mathata thromboembolic;
• amenorrhea, oligospermia, hyperuricemia, mosese khubelu staining, azoospermia;
• conjunctivitis, keratitis, lacrimation;
• pheriferale neurotoxicity, sethoathoa, coma;
• edema, reversible alopecia, photosensitivity, letlalo hyperpigmentation, lekhopho, ho hlohlona, utloe bohloko bo boholo, lekhopho, etymology, mongobo epidermis;
• dermatitis, lekhopho, bronchospasm, letlalo e phallang, anaphylaxis;
• Local phlebitis, tšoauoa ho ruruha, fleboskleroz, thrombophlebitis, bohloko sebakeng seo, dinama tse nyenyane tse necrosis;
• polyuria, nocturia, dysuria, necrosis ea senya lera la, hematuria, boemong bo sa thabiseng, a bohloko ho ntša metsi;
• erythematous striation sebakeng seo ente;
• mokhathala, malaise, feberu, chills, ntshetsopele ya lymphocytic kapa myelocytic kankere ea mali (a hlobaetsang le), hyperuricemia, tides, nephropathy;
• seso 12 duodenal / gastric, biliary sclerosis.

matšoao a overdose

ke seo lipontšo tsa overdose ho etsahala'ng ha u sebelisa palo e khōlō ea "Doxorubicin" lithethefatsi? Litaelo tsa Sebelisa e bolela hore e overdose ea chelete ho ka etsa hore le matšoao a nang le chefo e li bonahatsoa ke tsamaiso tshilong ya dijo, ekasitana le ho myelosuppression matla. Ho phaella moo, tekanyetso e phahameng ea lithethefatsi e ka ba ho le bonolo haholo ho etsa hore lefu le a hlobaetsang le pelo.

E pheko ea ho lithethefatsi "Doxorubicin" ha e yo. Ka overdose angoa laolwa phekolo bontshang matshwao. Hape, ho e kena sepetlele 'me a tšoaroa ka lithethefatsi antibacterial.

ditshebeditsano lithethefatsi

Na hoa khoneha ho kopana le lithethefatsi tse ling tse lithethefatsi "Doxorubicin"? Litaelo bakeng sa ho sebelisoa e bontša hore ha u sebelise sesebelisoa sena hammoho le lithethefatsi tse ling tse cytotoxic hangata e bontšoa tseloe bona toxicity.

Ha motsoako lithethefatsi le lithethefatsi tse ling tse cytotoxic, eo na le cardiotoxicity (mohlala, "Fu" kapa "Cyclophosphamide"), hloka boalosi hloko pelo ea nakong tsela eohle ea phekolo.

"Streptozocin" eketsa halofo ea bophelo "Doxorubicin".

The phekolo "Doxorubicin" mokuli a ka bontsha matshwao a hlobaetsang hemorrhagic cystitis mora kalafo "cyclophosphamide", hammoho le matla lipono tse makatsang tsa toxicity sebete ka mora kalafo "mercaptopurine."

Ho sebelisoa ha "Paclitaxel" pele selelekela sebele ba "Doxorubicin" le ka qholotsa ho eketseha ha ea mahloriso mali a qetellang.

Seo lithethefatsi ba thibetsoe ho sebelisa lithethefatsi "Doxorubicin"? Litaelo bakeng sa ho sebelisoa (bakeng sa liphoofolo e sa abeloa) e tlaleha hore thulusi ena ha ea lokela ho tsoakane le lithethefatsi tse ling. Ka mohlala, e ke pharmaceutically nyalanang le "heparin", "Dexamethasone", sodium succinate, "hydrocortisone", "cephalothin", "aminophylline", "Fu" le ho sebelisa lithethefatsi tse ling tse anticancer.

Ha ho kopantswe le ente e phele ka ho sa bongata ba kokwanahloko e khoneha bongata ba kokwanahloko boikatiso le eketseha liphetoho lehlakoreng le fokotseha antibody tswakana ka 'mele oa mokuli ka lebaka la tšebeliso ea ente e.

likhothaletso itseng tabeng ea ho sebelisa lithethefatsi

Seo u lokelang ho se tseba pele ho sebelisa "Doxorubicin-Lance"? Litaelo bakeng sa ho sebelisoa e bontša hore ka tsela ea kalafo mahlahana antineoplastic hlokahalang ho phetha go baya leitlho ea kamehla ea mosebetsi sebete, setšoantšo sa pheriferale mali, ECG le tsa ultrasound ba pelo.

thekiso maemo, mokhoa oa polokelo le raka, athe-bophelo

Moo lokela lithethefatsi "Doxorubicin-Lance"? Litaelo bakeng sa ho sebelisoa e tlaleha hore thulusi ena e lokela ho a 'na a ka omeletseng le e lefifi sebaka seo mocheso ha feta likhato tse hlano.

moriana o le e lokolloa ka na bapharmasi ke lengolo la ngaka feela. raka, athe bophelo ba eona ke lilemo tse peli.

Theko le analogues

Litsenyehelo tsa ho ba ea lithethefatsi le ho nkoa 120-150 li-ruble tse 5 di ml. Haeba ho hlokahala hore ka ho nkeloa sebaka ka a kang "Doxorubicin-Teva", "Lachema Doxorubicin", "Onkodoks 50", "10 Onkodoks", "Doxorubicin-Ebewe", "CRC-Doxorubicin" le ba bang.

ulasan pelanggan Consumer tsa meriana

Hona joale u tseba ho sebelisa lithethefatsi "Doxorubicin". Litaelo bakeng sa ho sebelisoa le poloko ea lithethefatsi li ile tsa hlahisa mona ka hodimo.

Haholo palo e khōlō ea ulasan pelanggan moreki amanang le itšoare ka tse batlang li tebile bohloko hore etsahala nakong kalafo le moriana. Ho liphello tsena ke ho kenya letsoho ka hare le lekala, e tšoarellang halelele ikutloa kula, ho shoeloa ke moriri le sebopeho sa liso tsa ka maleng ka libaka ea ente.

Ka molaetsa tse ntle ba ka seoelo haholo. 'Me sena se ha se makatse, kaha ho atleha ha anticancer lithethefatsi lokela ho hlahloba e feela ea nang le phihlelo ngaka, e thehiloeng ka palo e kholo ea lintlha fapaneng: mofuta oa monotherapy kapa phekolo motswako, le kankere, boemo ba mokuli,' me liphello tse ling tsa nako e telele.