"Indomethacin" (matlapa): litaelo bakeng sa ho sebelisoa, ea sebele

E mong oa baemeli ba sehlopha sa nonsteroidal lithethefatsi-ba khahlanong le a hlabang ke lithethefatsi "Indomethacin" (matlapa). Ka lebaka la ho-ba khahlanong le a hlabang lona, analgesic le litla antipyretic tsa tšebeliso lona bakeng sa kalafo ya mafu a hlabang, imolla bohloko, fokotsa ho ruruha le ho tsosolosa kopanetsoeng tsamaiso.

Tlhaloso ya ba lokisetsa ho ea

Ba ka sehloohong a sebetsang a motsoako oa lithethefatsi ke indomethacin, e amana indole derivatives acid e acetic. Ka hare ambalaji moriana o "Indomethacin" hlalosang e le likarolo matlapa tataiso le sireletsang enteric barbotage eo lumella moemeli a sebetsang a lokela ho lokolloa ka intestine le, ba eta ka mpeng. Sebopeho sa matlapa ho potoloha, biconvex, ka holimo koahetsoeng ka khanya-sootho khetla.

Tablets tse dosages tse ngata: 25 mg,, 50 mg, le 100 mg, ea indomethacin. Fumaneha ka likotoana tse 10 kapa 40 ka pakete.

mefuta eohle litekanyetso li behoa

Ho feta moo matlapa, ho na le mefuta e meng ea "Indomethacin" ho lokisetsa bakeng sa ho sebelisoa tsa molomo, ho etsa mohlala ka 'matlafalitseng ho lokolloa komiki litekanyetso li behoa ea ea 75 mg,. Bakeng sa tsamaiso rectal, suppositories li sebelisoa ka lethal dose ea la 50 mg,. Bakeng sa dikopo ntle bōptjoa mafura 5% le 10% le 3% gel.

mochine oa bohato

The moriana o ke nonsteroidal antiinflammatory moemeli systemic bohato, le nang le antiinflammatory, decongestant, analgesic le litla antipyretic. Khomaretse moriana "Indomethacin" (matlapa) tataiso mochine kenyelletsa ditokiseletso tlhaloso ya tšebetso ea oona ba mafolofolo motsoako o amanang le ea fokotseha ka mosebetsi cyclooxygenase tsa mofuta 1 le ea 2. Ka lehlakoreng le leng, potlakisang tsebetso ea lik'hemik'hale ena e na le phello fokolang haholo ka acid e arachidonic eo ho fokotsa ho sokoloha lona ho prostaglandin. dintho tsena bakela ho ruruha le bohloko.

lipontsuoa Indomethacin antiplatelet e le hantle, fokotsa platelet clumping ea lisele tsa mali. Ntho attenuates bohloko ka bohloko kopanetsoeng le boemong ba le khutso le mobile, ho fokotsa hoseng ho satalla le ho ruruha, ho eketsa mefuta e fapaneng ya tshisinyo. Action indomethacin ikemiseditse ho fokotsa ho ruruha. Phello lebetsoeng le e fuoa ka letsatsi la bosupa la kalafo, matlapa lithethefatsi.

hore tsoarang

Thehiloeng mochine oa bohato, "Indomethacin" Letlapa taeo e pukwanana khothalletsa tšebeliso bakeng systemic kalafo ya:

• articular lefu;
• mafu a hlabang ea tsamaiso ea musculoskeletal bakoang ke ruruhisang, psoriatic, ruruhisang, mike mike ramatiki, mahetla hoammeng, ankylosing spondylitis, lefu kopanetsoeng ka deforming osteitis le uretrookulosinovialnom lefu;
• mafu a holofatsang ea tsamaiso ea musculoskeletal bakoang ke osteochondrosis le radicular lefu, osteoarthrosis manonyello le, ka ntle ho noka mme intervertebral arthrosis;
• diffuse lefu, koahetse dinama tse nyenyane tse connective;
• rheumatism;
• suppurative hlabang diso ea mekotla periarticular le tendons;
• matšoao a hlobaetsang le bohloko ba ka tlaase morao 'me le likarolong tse ling ea la mokokotlo ha sciatic neuralgia le methapo ea kutlo tse ling, ho ruruha ha mesifa ea;
• sithabetsang ho ruruha ka lisele tse bonolo kapa manonyeletso.

E ka u thusa ho sebetsana ka katleho le hlooho e opang, matsatsing, leino, lefuba.

E le moemeli ea thusang bakeng sa mafu a tšoaetsanoang le a hlabang tse kang pharyngitis, tonsillitis, nattokinase sebedisa moriana o "Indomethacin" (matlapa). Ho bonahala e kenyeletsa ho phekola cystitis, adnexitis, prostatitis.

Lithethefatsi ke atlehang tlosa febrile lefu amanang le lefu Hodgkin e, lymphoma, metastatic lihlahala, ha o se a sebetsa ho paracetamol le acetyl salicylic acid e.

Tsela ea ho nka

"Indomethacin" moriana ka matlapa e laolwa ho mokuli ka litekanyetso li behoa khetheha e thehiloeng ka tekanyo e maloetse. Ka kakaretso, batho ba baholo ho qala ka ho amohela lethal dose e le ba 25 mg, ka makhetlo a mararo letsatsi ka mor'a lijo.

Ha e le hantle tsa kalafo e haella phatlalletsoang habeli litekanyetso li behoa ho 50 mg, 3 linako tse ling ka letsatsi. Palo e kahodimodimo lumelleha lethal dose lokela ho sa feteng 200 mg, indomethacin. Ka mor'a se ileng sa ntlafatsa bohlokoa bakoang ke phekolo ea lithethefatsi, kalafo lokela ho ile a khaotsa ho libeke feela ka mor'a 4 sebedisa nako fetileng kapa fokotswa lethal dose. Ha bakuli ba nka lipilisi bakeng sa nako e telele "Indomethacin" taeo pukwanana khothalletsa ka lethal dose ea 75 mg, ea a sebetsang a motsoako ka letsatsi.

kalafo ea bana

Ngoana letsatsi lethal dose balwa ka ho ata 2,5 kapa 3 mg, ka 'mele oa hae le boima, ho nkuwa bakeng sa linako tse 3-4. Bakeng sa sehlopha ka seng lilemo a fana ka tshebediso ya e ka lekhetlo la pele lethal dose ea letsatsi le letsatsi:

• bana ba 3 ho ea ho lilemo tse 7 laolwa ho tloha 50 mg, ho 75 mg,, e leng tšoana le matlapa a 2 kapa 3;
• bana ba 7 ho lilemo tse 12: ho tswa ho 75 mg, ho 100 mg,, e leng tšoana le matlapa 3 kapa 4;
• Bana ba lilemo tse 12 tseo ke li behetsoeng, ho tloha 100 mg, ho 125 mg,, e leng tšoana le matlapa 4 kapa 5.

Ka matsatsi a seng makae pele, u lokela ho fumana hore na ea lithethefatsi 'meleng oa ngoana, kahoo sebelisa lethal dose e nyenyane ea meriana. Ka nako ea phekolo le "Indomethacin" (matlapa) taeo e kgetha ka nako ho tloha matsatsing a 6 ho 7.

Features baeti ba fihlelang

Tabeng ena, ho na le ke le monyetla oa liphello tse mpe bozongisela ho bolela "Indomethacin" ka matlapa a, ho molemo a se ke a sebelisa bakeng sa ho phekoloa rheumatic feberu a hlobaetsang ka bongoaneng. Ba tsoela pele ka lebese, ho motsoako a sebetsang a kena mali ea ngoana, a eketsa nyooko fisioloji ka lesea le hlōloa ha lisele tsa sebete. Ho qoba sena, hlakola kanyeso.

Batho ba hōlileng, bakuli ba sebete kula, a liphio, pampitšana tshilong ya dijo, matšoao dyspeptic, kgatelelo ya madi, congestive ha pelo ka mor'a ho buuoa, lefu Parkinson, sethoathoa, mokhachane ka ke le II trimester ha abela Indomethacin kalafo e hlokahalang ho hlokomela boemo ba phelang. Ho ke ke ho hlokahala ho laola mosebetsi wa litho tse mathata, hang mong le e mong matsatsi a 7 ho hlahloba mali pheriferale.

Haeba nakong e fetileng ke alejiki ho bao e seng steroidal lithethefatsi-ba khahlanong le a hlabang, lithethefatsi "Indomethacin" (matlapa) e khethiloeng ka linako tse ling litaba.

Re u se ke ua ho kgothaletsa ho phetha mosebetsi oa kotsi ka kalafo ea, jwalo ka khathatseha hloko le ho psychomotor mosebetsi.

Ha u ka ke ua nka

Ho na le mafu a ka eo meriana contraindicated "Indomethacin" (matlapa). e sebelisa ke ke ha khoneha:

• hypersensitivity ho indomethacin;
• ka ho ba teng ha erosive le diso ulcerative ea tsamaiso tshilong ya dijo ka mohato hlobaetsang;
• ha "aspirini rapeloang ka boraro", tšoauoa ka mamellane ho acid e acetylsalicylic, polyps nasal le bronchial asma;
• ka hemodyscrasia;
• ha phatlalletsoang phetoho ea sebete 'me liphio;
• ka lieha ya letsoai le sephalli ka khoneha edema pheriferale;
• ka matla a sa foleng ho hloleha tlhaku ea myocardium ea;
• ka khatello ea phahameng;
• bronchial asma;
• ka ho ruruha ha manyeme le;
• ka III trimester tsa emara ngoana;
• kanyeso;
• bana ba ka tlaase ho feta lilemo tse 3.

liphetoho tse bohloko

The meriana "Indomethacin" (matlapa) o ka amanang le liketsahalo tse bohloko hampe amang boemo ba 'mele oa motho. Bakeng sa liphetoho ho tloaelehile hore batho bohloko kenyeletsa ho nyekoa ke pelo, ho ipolaisa tlala, bohloko ka mpeng, bloating, pipitlelano, indigestion.

Maemong a sa tloaelehang, litla-morao ka etsahala erosive le diso ulcerative, tsoa mali le perforation ea mala le mabota mala; applasticheskoy kapa haemolytic khaello ea mali, leukopenia, thrombocytopenia, agranulocytosis, lekhopho, ho shoeloa ke moriri, letlalo ho hlohlona, sethoathoa, angioedema, bronchospasm.

Lipontšo tsa chefo epidermal necrolysis, ka seoelo haholo o ile a re anaphylactic makala, etymology nodosum.

Nakong ea kalafo e ka tsa fokodisa le tshebetso ya renal excretory le sebete, e leng eketsa ka tjhelete e ya bilirubin, e amanang le sebete transaminases.

Nako e telele ho sebelisoa ha sethethefatsi "Indomethacin" (matlapa) ha e qhelela ka thōko liphetoho bohloko amanang le meferefere robala, molikoalikoane, ho neuropathy pheriferale, hlooho e opang, pherekano, teneha kapele, mokhathala. Di tšoauoa ka clouding tsa cornea, conjunctivitis, utloa kholofalo, tinnitus, kgatelelo ya madi, edema.

Reviews

Ho bohlokoa ho latela melao eohle ea moriana, tsa kgetholla contraindications tsohle.

Ba tsoakane ka tumello ya "Indomethacin" ulasan pelanggan lithethefatsi. Tablets na litla feta lehlakoreng feta liforomo litekanyetso li behoa bakeng sa ho sebelisoa ka ntle. Ho feta moo, motho ea mafolofolo lithethefatsi amana inhibitors tsa cyclo-oxygenase 1 le ea 2, tse nkoang e sa sebetsa le ho etsa hore 'maloa a itšoare sa rateheng tsa pampitšana loewenapotheke-mala.

Rheumatologists le bakuli ba tsona ba, lingaka tse buoang hangata e laela lithethefatsi ncha ho tloha sehlopha sa oxicams. Ba thibela metsoako e cyclooxygenase mofuta 2 feela, e sa ame ea potlakisang tsebetso ea lik'hemik'hale mofuta 1, e leng etsa bonnete ba ho hlahisa prostaglandins hore sireletsa tsamaiso tshilong ya dijo. Ke ka lebaka leo oxicams ke tsa ntša kotsi ka tlase ho mala ho feta ho pheko "Indomethacin" (matlapa). Litaelo poeletsotlaleho mpe e akarelletsa tlhaloso ea litla-morao, empa sena ha se bolele hore ho phekola ba lokela ho bontšoa. Tsohle itšetlehile ka litšobotsi tsa phelang.

Bakuli ba bangata, sena se bolela ho pholosa ho tloha bohloko morao, myalgia, intercostal neuralgia, ha meriana e meng ha thusa. A litla mpe hoo e batlang e ha ho hlaha ho tswa ho phekola "Indomethacin" lithethefatsi. Reviews of matlapa a hlaphoheloa bakuli hlahiswa tse khothatsang. Leha kotsi ke kamehla o teng, 'me feela ngaka ka ho laela ea baeti ba fihlelang ho ba joalo lithethefatsi e tebileng.

analogs

Tablets le motho ea mafolofolo ntho Indomethacin tse hlahisoang ke lik'hamphani tse ngata linaheng tse ling le tse ruuoang tse kang khampani "Sopharma", "Ludwig Mekle" "Nycomed", "Farmahim", "Berlin Chemie Menarini," "Altfarm". Feela e mong le khoebo ea lithethefatsi lebitso la eona, sebopeho lona thusang dikarolo. All nyarelang ka bonahala e tšoanang bakeng sa tšebeliso, litla-morao, contraindications.

Lithethefatsi ho fetisisa ratoa "Indomethacin Sofarma" (matlapa). Hatisa ka lethal dose ea la 50 le 100 mg, ka ho "Sofarma" (Bulgaria). Le bolela ho bao e seng steroidal lithethefatsi-ba khahlanong le a hlabang.

E mong para ea seng ka tlase ho analogues ya tsebahalang - meriana "Indomethacin 50 mg, ea Berlin-Chemie" le "Indomethacin 100 mg, ea Berlin-Chemie". Hatisa ka dosages tse peli (50 le 100 mg,) ke khampani Setaliana "Berlin-Chemie Menarini".

Ka ho lokisetsa "Indomethacin" (matlapa) na analogues le tlhahiso ea Serussia. Ba di a fumaneha ka mefuta e fapaneng litekanyetso li behoa. ke counterparts ka sehloohong:

• "Indomethacin-Acre" lik'hemik'hale-meriana Plant JSC "Akrikhin";
• "Indomethacin-Altfarm", LLC "Altfarm";
• "Indomethacin-Biosynthesis", JSC "Biosynthesis";
• "Vero Indomethacin", OJSC "Veropharm".