Immunoglobulin E le bohlokoa lona fisioloji

Immunoglobulin E le ea bohlokoa fisioloji - lintho tse hlokang ho nahanela. Hona joale, ho na le mefuta e 'maloa ea immunoglobulins (lisireletsi). Ho na le mefuta e 'maloa ea lisireletsi hore li fapana ka mofuta wa ketso le mochine oa maloetseng-ba khahlanong le infective. Lisireletsi qholotsa pula le flocculation tsa qhibiliha lihlahisoa baktheria, agglomeration le agglutination corpuscular antigens (spirochetes, likokoana-hloko, protozoa le libaktheria). Ka lera seleng ea vibrios trypanosomes le tsitsitseng spirochetes immunoglobulins mehahong e itseng le motlatsi, a etsa hore platelet adsorption. Ka tloaelo ho, tsena mahlahana a tšoaetsanoang a ntse a dinama tse nyenyane tse lymphoid. The immunoglobulins ea litlelase G le M hammoho motlatsi ka hydrolyze spirochetes, trypanosomes, libaktheria le likokoana-hloko.

Phello ea lisireletsi ka pathogen e emisitswe ha e kena ka seleng, 'me ha bontša hore ho antigen holim'a seleng. Immunoglobulins ka matlafatsa kapa fokolisa hanyetsa boitshireletso ba phelang. Antigen-antibody rarahaneng eo e na le antigen feteletseng, etsa le phello e hlasimollang, 'me e rarahaneng le e fetang lisireletsi etsa hore ea baka mathata. Hangata ka ho fetisisa, e immunoglobulins ke sesosa sa mathata a autoimmune le alejiki.

IgE e tsa maiketsetso haholo-holo ka lisele tsa lera la mucous ea matšoafo, pampitšana loewenapotheke-mala, hammoho le ka nodes lebatowa lisele tsa mmele. Ka lekhetlo la pele, e le sehlopha sa arohaneng tsa immunoglobulin E ile a tsebahatsa ka 1966, 'me ka 1968, ho WHO e nkoa e le ikemetseng IgE sehlopha sa ba immunoglobulins.

sehlopha sena sa liprotheine tse fumanoang ka batho, litsoene le ba bang ba liphoofolo tse laboratoring. Boholo ba E immunoglobulin limolek'hule amahanngoa le lisele tse letlalo palo le basophils. Ho tloha ka tlas'a tloaelehile concentrations maemo immunoglobulin E ka serum mali a nanograms tse seng kae ka millitara, khopolo tsa motheo tsa sebōpeho sa molek'hule ena e fumaneha feela motheong oa ho ithuta liprotheine 'maloa myeloid. maemo tlaase haholo ea immunoglobulin E ka serum ho hlakile hore ho hlaha ho tswa ho ha e le hantle hore ho ke ke ka khona ho "khahloa" ho holim 'a lisele tsa tsona li le ka tieo tlama ho lisele tse palo le basophils.

Ho lumeloa hore Іg E ke sehlopha sa kgolo ya immunoglobulins eo ho hlahisa lisele tse palo le basophils ho ba le seabo kulisa. Boemo ba protheine ena ka serum ea bakuli ba eketseha allergy 'me hangata feta 350-800 U / mg,. Kakaretso IgE ntho e tloaelehileng eona bana ba ka tlaase ho lilemo tse likhoeli tse 12 ho fihlela ho 15 U / ml tse. IgE phetha karolo ea bohlokoa ka liphetoho la hypersensitivity hang-hang. Immunoglobulin E ntho e tloaelehileng ho batho ba baholo Range ho tloha 0 ho 120 U / ml tse.

Ho ea ka bopa dikgopolo tsa morao-rao, mosebetsi o ka sehloohong oa immunoglobulin E ke ho sireletsa 'mele ea lera la mucous e loketseng ho Tshebediso ya mabaka ea moo ea lero la mali mali le lisele tse effector. Likokoana-hloko li khona ho senya ka mola tšireletso ea hore etsa immunoglobulins tsa sehlopha sa A. Ka mor'a hore likokoana-hloko kapa libaktheria holim'a lisele tse palo tlama ho itseng sehlopha sa immunoglobulin E, ka lebaka la joalo lisele tse sebelisana palo fumana pontšo ho lokolla ba amines vasoactive le lintlha chemotactic, eo ka bakang ba retelehelang inflow ea e potoloha Ig tlelase G, motlatsi, eosinophils le neutrophils. Eosinophilic chemotactic Ntlha e, e leng e ka lokolloa liseleng tse palo, e khothalletsa ho bokella eosinophils le ho timetsoa ha liboko. Ho lumeloa hore ho IgE adsorbed holim'a parasite ho, hohela macrophages leboha ho FC-receptors.