E le sehlopha se le pharaletseng la lithethefatsi - lithibela-mafu tetracycline

lithibela-mafu Tetracycline - ke sehlopha se seholo sa lithethefatsi. Medicaments na le tšoanang sebopeho lik'hemik'hale. Re lokela ho hlokomela hore chelete tsena ke se seng sa libaka tse e etellang pele har'a manyenyane sephara ea mosebetsi oa lithethefatsi.

Tetracycline lithibela-mafu. tlhaloso

Lithethefatsi sehlopheng sena ba le phello e tepeletsang maikutlo ka ho ikatisa le ntshetsopele ya a mob mobile-mpe, a mob mobile ea HIV libaktheria, diithupa (ea acid), likokoana-hloko kholo, libaktheria tse ling. dihlopha e akarelletsa lithethefatsi tse kang "chlortetracycline hydrochloride", "hydrochloride Oxytetracycline", "Tetracycline" le ba bang. ho ithuta lithethefatsi ile a qala ka 1948. Ka lebaka la mathata a mang ka ho lithethefatsi tsa maiketsetso tsa kajeno li Bōpiloe sebelisa biosynthesis. lithibela-mafu kaofela tetracycline fapana tlhaku amphoteric. boleng bona tsa mantlha e loketseng ho sehlopha dimethylamino. meriana hae bontša thepa ea asiti e loketseng ho phenol hydroxyl ea D-lesale. E le amphoteric komponeng qhibilihang ka har'a ka acid e le a alkali, eaba ba etsa le letsoai. Ba, le eena hydrolyzed ka ditharollo ea metsi. maemo phahameng thibela acid e hydrolysis thulaganyong, le pula botlaaseng precipitate.

metsoako All tetracycline na spectra tse tšoanang mong ho e mong. Ka limolek'hule tsa hydroxyl phenol etsa hore phetoho mmala ke itsoara joang ka chloride ferric (3). lithibela-mafu Tetracycline bola ho theha a alkali izotetratsiklinov. Ka lehlakoreng le leng, sena se tsamaea le leruo la ho se ka ho penta le. kakaretso itsoara joang ka bath ya metsoako tsohle tetracycline. Litokisetso khetholla ho tloha nngwe le e nngwe tse ling tse ka etsahala ka lebaka la staining fapaneng tlas'a tšusumetso ea acid e sulfuric (concentrated). Ena e tsamaea le sebopeho sa metsoako, 'mala bakeng sa e mong le e tetracycline ka' mala oa eona. Ho joalo, ho etsa mohlala, ho e 'ngoe ho na le pherese-e khubelu Hue, bakeng sa e' ngoe - pherese. E 'ngoe ea litšobotsi tse ka e nkoa e le lithethefatsi bokhoni ba ho fluoresce tlas'a tšusumetso ea UV leseli. E atisa ho sebelisoa e le bopaki ba bonnete ba bona.

Diokobatsi thepa tetracycline

ho lokisetsa sena e fapana manyenyane ka ho lekaneng sephara ea mosebetsi. phello ea oona bacteriostatic ka lebaka la thibelo ea protheine tswakana libaktheria causative. mosebetsi lithethefatsi ho bontšoa amanang le ho aerobiki libaktheria a mob mobile ea HIV, ho akarelletsa le mefuta e hlahisa penicillinase. Lithethefatsi hape ama libaktheria mob mobile-negative. Bontša ho hanyetsa lithethefatsi likokoana-hloko tse nyenyane, li-fungus tse ngata 'me a' maloa a mefuta e meng.

Ba bang ba melao lithibela-mafu kenoa. liphetoho tse bohloko

E kgothaletswa ho sebelisa lithethefatsi ka lethal dose ea la dikgerama 0,3 tsa matsatsi a mabeli pele, dikgerama 0,2 tsa ka makhetlo a mahlano ka matsatsi a latelang. Qhoshola (subacute le a hlobaetsang le bonolo) tseleng e beuweng ho 5 g,, le mefuta e meng - ho 10. Ho buelloa ho nka moriana pele kapa nakong ea lijo. Khahlanong le semelo sa ka etsahala hore ebe koatile mpeng, ho hlatsa, ho nyekoa ke pelo.