"Dzhakavi" (ruksolitinib) theko counterparts. Moo ho reka theko e tlaase Dzhakavi

Lithethefatsi le lecha "Dzhakavi" etsoa ke khampani Switzerland "Novartis" e atile har'a lingaka ba ho tšoara kankere.

Ruksolitinib, ba ka sehloohong ba sebetsa ka mafolofolo motsoako oa se boletseng se bolela - protheine tyrosine kinase sesitisa. Ho atleha ho phekola mafu a tse amanang le splenomegaly, myelofibrosis hammoho (ho akarelletsa le sa mathomo le se mahareng, e ntshetswa pele ka lebaka la thrombocythemia bohlokwa le polycythemia).

Bafuputsi ba ela hloko hore tshebediso ya lithethefatsi fokotswa spleen boholo ke 35%, e ile ea eketseha ba phela le boleng. Kahoo toxicity ea motsoako o le mafolo-folo e leka-lekaneng ho bapisoa le lithethefatsi tse ling tsa manyenyane tšoanang ho nka khato.

Moo o ka "Dzhakavi" lipilisi reka theko e tlaase

Empa pele ba tsoela pele ho le tlhaloso ea moriana, re ke ke ra bolela ka ho phekola mafu a ka lintho tse tebileng ho hloka e ngata ba lithethefatsi theko e phahameng, 'me sena a ka se bona empa e baka ngongoreho ea eona har'a bakuli. Lahla meriana bohlokwa ke ke ha khoneha, empa hape ho bona hangata ho bang thata haholo. Kahoo, ka drugstores la Moscow ka pilisi e "Dzhakavi 'theko e qala ho tswa ho tse 100 000 li-ruble.

Ho pholoso ba boemong bona ka tlang WWW.ONKO24.COM saeteng moo o ka reka sethethefatsi seo 'karela bitsoang kateng. Ha ho tšoana li feletseng, 'me phello e tšoanang ka kōpo ea ho tla ja chelete theko e tlaase haholo. 'nete ea hore tlhahiso ea karela ha jara litšenyehelo tsa ho tsoelang pele, lisebelisoa liteko,' me ho phahamiswa e lumellang bahlahisi lona ho sebetsa tlas'a lengolo official, ho lefa khutlela ho lokolloa ha moriana ka theko e tlaase.

Dosing le lethal dose ho lokisetsa

Bakuli ba lokela ho hlokomela hore ho sebelisa "Dzhakavi" moriana e ikemetse ea ja lijo. 'Me haeba ka nako e balletsweng ke bakeng sa seno hlōleha letlapa, u ke ke ua nka lethal dose habeli oa bona. Ho ke ke ha hlokahala hore ka lebaka la battlefield ena le baeti ba fihlelang ho le hlahlamang.

The lethal dose ea pele ea lihlahisoa tse hlalositsoeng li laetsoeng feela ke setsebi sa, ho itšetlehile ka entsprechen mali - pleitelete. Ka tloaelo, ke 15 mg, (leq ipheng 2 ka letsatsi.), Ho akarelletsa ho 100-200 / NL, ha e palo ya tse fetang 200 / NL - 20 mg,. Ha palo ea li-platelet ke 50-100 / NL, ho palo e kahodimodimo ea pele lethal dose lokela ho sa feteng 5 mg, habeli ka letsatsi. The lethal dose lebetsoeng le tla ditlaleo hapa ho lithethefatsi "Dzhakavi" litaelo bakeng sa ho sebelisoa ha ea lokela ho feta 25 mg,, nkiloeng habeli letsatsi le letsatsi.

Ka kakaretso, kalafo lokela ho ho phethahatsoa count ya kamehla ruksolitinibom ka lisele tsa mali (erythrocytes, leukocytes le liplatelete) ka mor'a libeke tse 2-4 ka nako ya khetha ea lethal dose 'me ka nako eo, ho itšetlehile ka hore ho bonahala litleleniki tsa.

Contraindications

Bakeng sa tshebediso ya lithethefatsi "Dzhakavi" ho na le contraindications itseng:

1. Boimana le diabolololo.
2. lilemo le mamello le monyenyane ho lilemo tse leshome le metso e robeli la lilemo.
3. Personal ruksolitiniba mamellane kapa karolo tse ling tsa ho lokisetsa ya.

Joalokaha ho boletsoe ka ho sebelisa "Dzhakavi" likarabo sa litsebi le teng, ho bolela lokela ho sebelisoa ka hloko ea ho phekola bakuli le ho hlōleha renal kapa hemodialysis. Ka sehlopha e tšoanang le kenyeletsa bakuli ba thrombocytopenia, neutropenia le khaello ea mali.

litla-morao

Ka kopo ya, joalokaha ho bontšitsoe khomaretse "Dzhakavi" taeo, hangata ka ho fetisisa a hlokomela latelang liphetoho e bohloko:

• mosese pampitšana tšoaetso ea;
• khaello ea mali;
• neutrophils;
• thrombocytopenia;
• tsoa mali (ho akarelletsa le ho longoa, nko le mali intracranial le hemorrhage ka pampitšana ea gastrointestinal);
• nona;
• ho tsekela;
• hypercholesterolemia;
• hlooho.