"Dopamine" - ke eng seo? "Dopamine": amohele taeo, kopo, theko

Lithethefatsi "Dopamine" shebahala joaloka bonaletsang phofo ea 'mala o mosoeu le monko o batlang e utloahale ea acid e hydrochloric. foromo ena e na le ka mokgwa wa hydrochloride. "Dopamine" - ntho qhibilihang ka har'a ka metsi 'me ba noa joala. E angoa ke alkalis, mahlahana a tse fapa-fapaneng oxidizing le matsoai tšepe. Ho bonahala le contraindications ho tshebediso ya lithethefatsi "Dopamine", thupelo ea ka e sebelisa li kenngoa ka har'a lingoliloeng tsa rōna.

Ho bolela o ile a ntša ka Infusion tharollo mamelisise.

litšobotsi tse diokobatsi

"Dopamine" - ntho, e neurotransmitter. Ka thepa tshilong ya dijo tsa dopamine ke selelekela adrenaline le noradrenaline. Lithethefatsi ama receptors ngollana, 'me ka concentrations phahameng kgothaletsa mosebetsi α- le β-adrenoceptors. "Dopamine" mosebetsi o ikemiseditse ho:

• tokafatso ea pheriferale vascular hanyetsa;
• eketsa khatello systolic mali;
• tlhotlheletso ya lebelo leo pelo;
• eketseha khumo cardiac;
• nyenyane fetola lebelo leo pelo;
• bohlokoa oksijene phepelo.

"Dopamine" hape kgothaletsa ho phalla ea mali ka methapo ea boko, pelo, liphio le mala. Eketseha sekhahla glomerular karaoke set le sodium excretion ke a liphio le.

"Dopamine" - hore ho itingoe lijo-a sebetsa ho ea lithethefatsi. Ka mor'a metsotso e 5-10 ka mor'a kea / v Le Infusion tshebetso e qetella. The halofo bophelo - hoo e ka bang tse peli metsotso. Halofo ea ntho e le sebedisana ka le protheine ka lero la mali mali. Lithethefatsi fetisa metabolism potlako a thulaganyo liphio, sebete le mali lero la mali ka lebaka la tšusumetso ea Mao le catechol-O-methyltransferase boemong ba ho se metabolites khathetseng moeeng le e mafolofolo e hlahisoang ke a liphio le. A kotara ea tšebeliso ea lethal dose e sokolohela norepinephrine ka adrenergic hlaha methapo ea kutlo. Ka lebaka la ho felisa le mafolo-folo ha e bokella ya lithethefatsi ka 'mele oa motho, esita le ka mor'a nako e telele ea baeti ba fihlelang ho.

"Dopamine": kopo

Ho bonahala ho bozongisela:

• mefuta e sa tšoaneng tsa makala, tse kang e sithabetsang, cardiogenic, postoperative, hypovolemic, endotoxin.
• Hlobaetsang vascular le ha pelo.
• Tlaase cardiac khumo.

"Dopamine" le cardiogenic makala le litlhoko tse khethehileng, ho eketsa myocardial contractile mosebetsi.

Lithethefatsi o laolwa entoe. 125 kapa 400 di ml ea liphesente tse hlano tharollo tsa sodium chloride kapa tsoekere tharollo hlokahala ka 25 kapa 200 mg, ka ho latellana. Kahoo, 1 di ml ea tharollo fumana 200 kapa 500 .mu.g ntho. Ha mokuli a ke ke a laoloa meqolo e khōlō ea mokelikeli ka etswa tharollo feta khobokellane e le hore 1 di ml micrograms 800 e ne e le "dopamine". Ho etsa sena, nka 200 mg, ka ho ya ka 250 di ml tse tharollo. Tekanyo ea selelekela fihla 1-4 ug / lik'hilograma ka motsotso ho e 'mele boima karolelano ea lik'hilograma tse 70 (2 ho 11 marotholi a ya 0.05% tharollo kapa ho tswa marotholi 1.5 ho 6 of 0,08% tharollo). The phekolo litekanyetso li behoa - ho tloha 5 ho ea ho 9, mg / lik'hilograma ka mets 1. Litekanyetso li behoa "Dopamine" 10-15 .mu.g / lik'hilograma ka motsotso na le thuso ka vasodilation le hypotension. Sekhahla tsamaiso ka eketsehile ho tse 18 .mu.g / lik'hilograma ka motsotso. The Infusion nka sebaka se se nang tshitiso le koahela ea nako ho tloha matsatsing a lihora tse 2-3 ho 1-4 kapa ho feta. The lethal dose ka letsatsi se ke feteng 800 mg,. Ha ho qaloa ho "Dopamine" e neng e tšoaretsoe ECG go baya leitlho. Boikemisetso ba ho lethal dose 'me tekanyo ea tsamaiso e ka khatello ea ea bohlokoa, ho otla ha pelo, khumo cardiac, ho otla ha pelo le diuresis. Ha hypotension ha a hlaha, 'me fokotseha moroto khumo, lethal dose lokela ho tsa fokotswa.

Contraindications

moriana o contraindicated ka ketsahalo mathata tse kang:

• arrhythmia;
• pheochromocytoma;
• prostatic hypertrophy;
• koalo glaucoma.

litla-morao

Selelekeleng sa ntho ka tekanyetso e khōlō, boemo bo phahameng ba "Dopamine" ho ka etsa hore liphello tse, ho akarelletsa le:

• tremor;
• tachycardia;
• vasospasm;
• arrhythmia;
• tlōlo ea morethetho matšoafo;
• anginal le hlooho;
• psychomotor pherekano ;
• liponahatso tse ling Adrenomimeticalkie bohato.

Ho tloha ka ho felisoa ha "Dopamine" e sebetsang, matšoao a ka hodimo tsa nyamela ha theola lethal dose kapa khaotsa tsamaiso ya moriana. Ha morethetho e robehile, ho ke ho hlokahala hore ho sebelisa lithethefatsi antiarrhythmic, ho akarelletsa le "Verapamil", "lidocaine" le ba bang. Extravasation tharollo "Dopamine" ho ka etsa hore necrosis ea subcutaneous adipose dinama tse nyenyane tse 'me ba letlalo.

lemosa

"Dopamine" nakong ea bokhachane ka behilweng feela ha tieo hlokahala kalafo bakeng sa 'mè oa,' me phello e phekolo e phahame ho feta e kotsi ho lesea le.

Fresh tharollo lokela ho ba le botenya sebeletsang pepeneneng le haelloa extraneous Hue.

Tsoa hong kalafo le lithethefatsi tse ling

lithethefatsi ba ka 'na ho ho nkoa ka ka ho tšoanang le le glycosides cardiac le diuretics (mohlala, furosemide le tse ling). Hypovolemic makala hloka ho qaloa ho "Dopamine" hammoho le kakaretso ea mali, lero la mali kapa lero la mali baemeli.

U se ke ua nka "Dopamine" ka nako e tšoanang le "cyclopropane", Mao inhibitors le mahlahana a ho thethebatso le selika-likoe ( "Halothane" le ba bang).

Seretse paakanyong Remix sa amoheleheng ka ditharollo alkaline ya lithethefatsi tse ling.

"Dopamine" - ya meriana hore e sebediswa feela ka lengolo la ngaka. theko lona itšetlehile ka litekanyetso li behoa 'me palo ea ampoules ka sephutheloana sa, ho tloha ka 80 ho ea ho li-ruble 300 ka pakete (5-10 ampoules).