Buserelin depo - Tlhaloso le kopo makgetheng

Le ho khetha lithethefatsi hormonal lokela ho thehoa ka ithuta ka hloko matšoao le boitsebiso ka hloko kotsi ea litla-morao.

Ho lokisetsa "Buserelin depo" bapisa ka mokhoa o amohelehang le tse ling tsa bokgoni lona phahameng le tlaase kgonego ya matšoao a boima. O e leng setho sa mahlahana hormonal anticancer.

The bohato diokobatsi ya moriana

bohato li entsoe ka buserelin antigonadotropnym,-ba khahlanong le androgenic,-ba khahlanong le estrogen bananeng, litla-ba khahlanong le hlahala. ntho lithethefatsi "Buserelin depo" ke tlhōlisano e tlame ho receptors ea lisele secreting gonadotropin-ho lokolloa Ntlha e (ba ka sebopeho sa lobe anterior ea pituitary tšoelesa).

Ka ho ba sethaleng pele input lithethefatsi e hlokomela keketseho e fetang ka ea mahloriso ya LH le FSH (gonadotropic hormona), abelwa ka pituitary, e leng isang ea eketseha genital Gomonov dikahare. Ka mor'a 14 - matsatsi a 21 ho emisang bolela gonadotropic mosebetsi ke feedbacks mpe, e leng isang phokotso e khōlō ea LH le FSH, 'me, ka lebaka leo, le ea fokotseha ka ho hlahisa li-hormone ho kopanela liphate. Kahoo, e motona testosterone mahloriso decreases, ho fihla boemong ba e thehilweng ka mor'a orchiectomy (ya kalafi faola). Basali lithethefatsi e le hantle "Buserelin depo" e theolela boemong ba estradioda tlhahiso ea tse teng nakong posklimaktericheskom.

Tšebeliso ea lithethefatsi le "Buserelin depo"

E e sebelisoa ka ho phekola kankere ea tšoelesa ea senya, maemong a mang, o ile a sebelisa ho thibela tlhahiso ea testosterone testes ena. Le boetse le sebelisoa ka ho phekola kankere ea matsoele (mafu hormona-itšetlehileng ka eona, e leng e tšoauoa ka tlhahiso ea phahameng oa estrogens kapa hlaha ka endometriosis). mafu a mang, ho tšoara "buserelina depo": fibroids uterine, endometrial hyperplasia, khanna lenaneo IVF ho phekola ho kgaolela basadi thari.

Contraindications le dikgothaletso e khethehileng

Hypersensitivity, orchiectomy, bokhachane, diabolololo. Mehato etellang lithethefatsi ka bolwetse pampitšaneng ena mosese ka boemo ba metastasis vertebral, kgatelelo ya madi, ke lefu la tsoekere, 'me ho tepella maikutlo. Buserelin depo le bokhachane - bopa dikgopolo tsa e lumellane.

litla-morao

Mokuli a ka ba tletleba ba malaise ka lehlakoreng la tsamaiso ea bohareng tšohile ka sebōpeho sa tšoaroa ke hlooho, ho tšoha, lefu la ho hlobaela, amnesia, fokotseha mahloriso, molikoalikoane, ho se tsitse ha maikutlo, 'me ka linako tse ling ho tepella maikutlo. E ka o ile a ikutloa tinnitus kapa hatella le leihlo, thothofatsang Pono kapa utloeng. Hangata e ka ba "chesang mahlaseli." Ka beke pele tsa kalafo ka basali hlokomela psevdomenstruatsiya, ka nako eo beha ka omile bosaling, khoneha lesapo demineralization, fokotseha libido. Tseo e leng banna, le maloetse ka 'na ba exacerbated ka pele 2 - libeke tse 3, kapa hlaha gynecomastia, fokotswa potency. Hantle e tšoanang e ka etsahala: ho ipolaisa tlala, mafu a dyspeptic. Buserelin depo le joala li lumellane. Bakuli le kgatelelo ya madi a ka eketsa khatello, ho otla ha pelo. From kulisa etsahala: ho hlohlona, lekhopho, bronchospasm, anaphylactic makala. Fetola laboratori ea litsupa: dyslipidemia, hyperglycemia, keketseho ea transaminases le bilirubin, thrombocytopenia le leukopenia.

Melao-motheo ea moriana

tsamaiso Intramuscular: laolwa hang-hang ka mor'a ba lokisetsa ho ea ho fanyeha ena.

- ha tšoelesa ea senya hlahala mong le e mong libeke tse 4 ho 4.2 mg,.

- Endometriosis - e hlahiswa ka hare ho likhoeli tse 4.

- ka uterine myoma -3 likhoeli.

- ho kgaolela basadi thari - 4.2 mg,.

tsamaiso Intranasal:

- bakeng sa kalafo ya mafu motšehali hlalositsoeng ka holimo - laolwa ho nasal cavity 900 mg, / ka letsatsi (lethal dose 'ngoe, makhetlo a 3 ka letsatsi), ho tloha 1 - 2 matsatsi a ho ea matsatsing.

- ho kgaolela basadi thari 600 mg, / ka letsatsi a, 1 lethal dose ka nasal cavity ka makhetlo a mane ka letsatsi. Ha matla a bontša thibela likepe ea tsamaiso ea ho ikatisa, lethal dose ea e fokotsehile ho makhetlo a 2.

Ba bang ba re:

- Phekolo ke kankere ea tšoelesa ea senya e etsoa bophelo bohle;

- lithethefatsi-ba khahlanong le androgen laolwa bakeng sa libeke tse 2. le bakeng sa libeke tse 2. ya kalafo le buserelin, thibela mathata a ka 'nang etsahala nakong ea libeke tse pele ea phekolo;

- ka nako ea pele ea kalafo ka basali e ka hlaha popelo cyst;

- lokela ho thibela ho ima le dithibela fumana meriana ho tšoara buserelin, empa pele likhoeli tse 2 ke ho hlokahala hore ho sebelisa mekhoa e bao e seng hormonal ya thibelo ya;

- le phello e ntle ka kalafo lithethefatsi tsa endometriosis buuoa kaha ka ho fokotsa maqhubu a ya relapses.

Sebelisana le lithethefatsi tse ling

Buserelin fokotsa phello ea lithethefatsi hypoglycemic. Ho ka etsa hore popelo hyperstimulation, haeba sebediswa hammoho le lithethefatsi se se akaretsang ho kopanela liphate li-hormone.