Asiti Zoledronic: diokobatsi sebetsa mme analogues

E o tsejoa hore bisphosphonates atisa ho thibela metsoako ntshetsopele ya bone bone metastasis le ho thibela ho lahleheloa ke masapo. E mong oa lithethefatsi e molemo ka ho fetisisa ho ba setho sa sehlopha sena - acid e zoledronic. Hape, ho na le ke bopaki ba hore lithethefatsi ena e na le angioneogenesis thibelo, tlhaselo hlahala, mamarello ea lisele hlahala ka dinama tse nyenyane tse lesapo, bitsang apoptosis, 'me ho na le synergy le chemotherapy.

Paakanyong 1 Vial

Zoledronic acid e monohydrate - 4,26 mg, Excipients - sodium citrate, D-mannitol.

pharmacology

E sesitisa ea lesapo resorption. asiti Zoledronic ke oa sehlopha sa mocha oa sehlopha sa tse phahameng tsa bisphosphonates. Ho na le phello e khetha ka lesapo. Ho fokotsa mosebetsi oa osteoclasts, ntle le etsa hore le phello e mpe ho sebopeho le litšobotsi tse ling tsa dinama tse nyenyane tse masapo. Sephetho sa bisphosphonates ka lesapo e thehiloe ka ho tšoana e phahameng ho mineralized lesapo, empa mochine nepahetseng ea limolek'hule hore o fana ka inhibiting mosebetsi oa osteoclasts, ho fihlela letsatsing lena ntse e e-s'o ile a ithuta. Hape ho na le e tobileng-ba khahlanong le hlahala thepa, etsa bonnete ba bokgoni ka lesapo metastasis.

Ka vitro fumanoa hore acid e zoledronic, bitsang apoptosis le inhibiting keketseho ea lisele tse nang le antitumor e le hantle ka ho toba ka myeloma, hammoho le ka lisele tsa kankere matshwao ya sefuba, ha fokotsa menyetla ea ho metastasis. Hape, acid e zoledronic na le thepa ea ho fokotsa ea mahloriso k'halsiamo ka hypercalcemia serum, eo ho bakoa ke hlahala e.

ho bonahala

• diso Osteolytic ka foci multiple myeloma.
• Osteoblastic, osteolytic tsoakiloeng lesapo metastasis ba lihlahala kgolo.
• Hypercalcemia, eo ho bakoa ke malignancy.

Contraindications

• Ho ima le ho nyantsha.
• Renal insufficiency.
• Bana le bacha (kopo tshireletso ha e so thehilwe).
• Hypersensitivity ho bisphosphonates le asiti zoledronic.
• Hlokolosi: renal ho se sebetse, bronchial asma, e amanang le sebete ho hloleha.

litla-morao

Khaello ea mali, thrombocytopenia, hlooho e opang, ho tsekela, conjunctivitis, ho nyekoa ke pelo, ho ipolaisa tlala, ho hlatsa, letshollo, bohloko lesapo, arthralgia, hypophosphatemia, hypocalcemia, feberu, lefu ntaramane, mokhathala, ho nona. Ea ho phekola bakuli le asiti zoledronic ka linako tse ling o ile a re ntshetsopele ya osteonecrosis ba mohlahareng (hangata ka mor'a ho kenella meno ho buoa).

Dosing

Intravenous rothele, 'me ka hare ho metsotso e 15, empa ha ho na tlase. Metastases tsa myeloma multiple kgothaletswa lethal dose of 4 mg, hang ka khoeli. Ha hypercalcemia, eo ho bakoa ke hlahala bolaeang, ka lethal dose of 4 mg, hang letsatsi le letsatsi.

lemosa

Hang lithethefatsi laolwa, ho ke ke ho hlokahala hore ho ho laola tsa mahloriso tsa magnesium, phosphorus, creatinine le k'halsiamo ka serum mali. Haeba ho khoneha, e kgothaletswa ho qoba ho buuoa meno.

asiti Zoledronic. analogs

Lithethefatsi "Actonel", "Aneldronat", "Areda lyophilisate", "Bonviva", "Bondronat", "Bonefos", "Klobir", "ksidifon", "Lindron", "Ostalon", "Ostealen", "Osterepar" "Pamidronate", "Pomegara", "Rizendros", "Strongos", "Tevanat", "Foroza" "Fosamax", "Fosfoteh", "Rizarteva".

asiti Zoledronic. theko

Ka tloaelo ho, libaka amehang kabo ea meriana ka molao, ho bontša le ditheko bakeng sa thepa ea bona. Empa, oddly ho lekaneng, theko ea acid e zoledronic hangata a bontša ka bang. Empa kgakanyo boleng lona fihla ka 14 likete li-ruble ka botlolo. Rekiswa ka na bapharmasi ke lengolo la ngaka feela.

Tlhahisoleseding ka holimo e reretsoe ho tlwaelanya basebetsi bophelo. Sehlooho sena se ke ka acid e zoledronic ha nka sebaka keletso ba tšoanelehang ba ngaka, 'me ke ke fana ka tiiso ea le phello e ntle ho tloha ho sebelisa moriana.