Streptomycin bakeng sa liphoofolo: litaelo tsa tšebeliso, tlhaloso le litlhahlobo

Ke bokae le ho tsoa ho eng e bontšoang meriana e joalo ea likokoana-hloko e le "Streptomycin"? Litaelo tsa tšebeliso, theko le morero oa meriana ena li tla tšohloa ka tlase.

Foromo, tlhaloso ea sehlahisoa sa liphoofolo

Moriana o bitsoang "Streptomycin sulfate" (bongaka ba liphoofolo) ke letsoai la setsi sa tlhaho, se hlahisoang ke li-fungus tse nyenyane haholo.

Ha ho rekisoa sehlahisoa sena se tla ka sebōpeho sa phofo e nyenyane kapa palo e tšoeu ea 'mala o mosoeu, tatso e utloisang bohloko, ntle le monko' me e qhibiliha habonolo metsing, novocaine le saline.

"Streptomycin" bakeng sa meriana ea liphoofolo e sebelisoa hangata ha ho hlokahala. Hape hoa lokela ho hlokomeloa hore e tsitsitse ka mokhoa o fokolang, empa o roba hantle ka litsela tsa alkali (ka futhumatsang) le li-acid tse matla.

Pharmacology ea moriana

Lithethefatsi "Streptomycin" e sebetsa joang liphoofolong? Tlhahiso ea litlaleho tsa tšebeliso ea hore moemeli o na le libtericidal le bacteriostatic tse nang le libaktheria tse ngata tsa gram-negative le gram-positive.

Katleho ea likokoana-hloko tsa lithethefatsi ena e bakoa ke matla a eona a ho thibela liprotheine ka lisele tse nyenyane tse boemong ba li-ribosomes. Hape hoa lokela ho hlokomeloa hore lithethefatsi ena ha e na tšusumetso ho mafu a bakoang ke Clostridia le likokoana-hloko tse ling tsa anaerobic, li-fungus, plasmodia, li-virus le rickettsia. Ho phaella moo, likokoana-hloko tse ling li bontša ho hanyetsa streptomycin e phahameng, 'me ho ikatisa libaktheria ho hanyetsa lithibela-mafu ho etsahala matsatsing a' maloa. Ka nako e ts'oanang, mefuta e mengata e thibelang e hlahisa qetellong ea khoeli ea bobeli ea phekolo. Ho thibela sena le ho felisa tšoaetso, o lokela ho sebelisa tekanyo e kholo ea lithethefatsi, hammoho le ho e kopanya le mahlahana a mang a likokoana-hloko.

Litlhapi tsa Pharmacokinetic tsa lithethefatsi

Na lithethefatsi "Streptomycin" e nkeloa liphoofolo? Litaelo tsa tšebeliso li bolela hore ha li tsamaisoa ka molomo ha lia kenngoa le ho felisoa ka ho feletseng ka maleng.

Ka liente tse entsoeng ka letsoho, motsoako o sebetsang oa meriana ena o kenngoa ka mali hang-hang, 'me o fumanoa le litlamong tse ngata tse nang le maqhubu le li-citities, bile, vitreous humor, urine le mahlo.

Ka mekhoa e metle ea ho ruruha ka bongata boemong bo botle, meriana ea mafu e ka finyella hoo e ka bang karolo ea 50 lekholong ea mali.

Ka tsoelo-pele ea meningitis streptomycin e khone ho kenella kahare ea mokokotlo ka tekanyo ea 10-50%.

Moemeli ena o feta ka har'a placenta habonolo feela. Ka mokhoa o tloaelehileng oa sebete, streptomycin e bokella ka holimo ho li-tubulate tse nang le mahlaba. Kaha mosebetsi ona o khathatsehile, o kena ka bile ka bongata, 'me ka cholecystitis ho na le lintho tse ka bang 85% tsa mali.

Methapo ea streptomycin ea meriana e mengata le litho tsa 'mele li bolokiloe lihora tse 8-13. Ntho ena e tlosoa kapele 'meleng ka mokokotlo.

Litlhaloso tsa ho beha lithethefatsi

Ke mafu afe a alafshoang ke lithethefatsi tse potsoeng? Koetliso ea tšebeliso ea lithethefatsi e re'ng ka see? "Streptomycin sulfate" e ngotsoe:

• Leptospirosis, tularemia, pneumonia;
• Mathata a maholo a likolobe le erysipelas, feberu ea catarrhal (e kotsi);
• Matšoao a li-diplococcal, mastitis, endometritis;
• Endocarditis, meningitis, postpartum le leqeba la sepsis;
• Actinomycosis ea likhomo le campylobacteriosis, hammoho le maloetse a mang, mahlaseli a causative ao a nang le kankere haholo ho streptomycin.

Lintho tse thibelang ho li sebelisa

U sa lokela ho fana ka meriana efe "Streptomycin" bakeng sa liphoofolo neng? Litaelo tsa tšebeliso, tse amanang le meriana, li bonts'a litlhaloso tse latelang:

• Ho utloahala haholo ha phoofolo ho ea likokoana-hloko tsa aminoglycoside;
• Boteng ba ho hlōleha ha pelo le metsoako ea renal.

Hape hoa lokela ho hlokomeloa hore lithethefatsi tsena li ke ke tsa kopanngoa le libaka tse ling tsa aminoglycoside (ho kenyeletsa le "Neomycin," Kanamycin, "Monomycin," Gentamycin ") ka lebaka la ho eketseha ha motlakase oa nephrotoxic.

Thupelo ea lithethefatsi "Streptomycin Sulfate" (bakeng sa ho sebelisoa liphoofolong)

Pele o sebelisa moemeli a le potso, o qhibiliha ka letsoai la saline, metsi a sa hloekang kapa tharollo ea 0.25-0.5% ea novocaine. Karanyo e latelang e latela: 0.25 g ya streptomycin le 1 ml ya solvent. Ka tsela, tharollo ea tsoekere e le ea ho qetela e thibetsoe.

Mekhoa e mengata haholo e ka ba e bohloko haholo. Tharollo e felile e ka bolokoa mocheso oa motsoako oa beke (ho molemo ho e boloka karolong ea sehatsetsing).

Ke lokela ho sebelisa Streptomycin joang liphoofolong? Thupelo ea tšebeliso e bolela hore tharollo e entsoeng e lokiselitsoeng e ka fanoa ka intramuscularly, hammoho le lihlooho tsa ka ntle, ka ntle, ka molomo, ka ho pota-potiloe ke pelo, ka hare ho intraperitoneally, intratracheally, intrauterine le ho se sebetse.

Lisele tse entsoeng ka letsoho tsa liphoofolo li kenngoa ka hare ho mesifa. Phekolo ena e etsoa matsatsi a 4-7. Meriana e tsamaisoa ka makhetlo a mabeli ka letsatsi ka nako ea lihora tse 12 ka litekanyo tse latelang:

• Khomo e nyenyane - 10 mg / kg bakeng sa batho ba baholo le 20 mg / kg bakeng sa liphoofolo tse nyenyane;
• Lipere - 5 mg / kg liphoofolo tse kholo le liphoofolo tse nyenyane tse 10 mg / kg;
• Khomo e kholo - 5 mg / kg bakeng sa batho ba baholo le 10 mg / kg bakeng sa bacha;
• Lintja, likolobe - 10 mg / kg bakeng sa batho ba baholo le 20 mg / kg bakeng sa liphoofolo tse nyenyane;
• Chicken - 30 mg / kg bakeng sa batho ba baholo le 40 mg / kg bakeng sa bacha.

Leptospirosis, sethethefatsi "Streptomycin" se tsamaisoa ka matsatsi a 4-10 ho tekanyo ea 25 mg / kg. Maemong a boima haholo, tjhelete ena e eketseha.

Hape hoa lokela ho hlokomeloa hore haeba ho hlokahala, meriana ena e kopantsoe le "Polymyxin", "Penicillin" le lithethefatsi tsa sulfonamide. Ho kopana ha lithethefatsi ho baka bothata ba liketso, hape ho thibela ho hlaha ha likokoana-hloko tse hanyetsang ho streptomycin.

Liketsahalo tse mpe

Hona joale o tseba hore na moriana ona "Streptomycin Sulfate" ke ofe. Litaelo tsa tšebeliso ea liphoofolo le tsona li hlalositsoe ka holimo.

Kaha li-injection tse entsoeng ka methapo ea pelo, ho ba le mefuta e mengata e potlakileng ea mafu ho ka iponahatsa ka likhomo , e leng tšoso ea bophelo bo botle le bophelo ba phoofolo. Ketsahalo ea mathata a joalo a amana le litšobotsi tsa 'mele oa hae' me ha ea itšetleha ka litekanyetso tsa lithibela-mafu tse sebelisitsoeng.

Hape, mathata a fapa-fapaneng a ka hlahisoa ka mor'a ts'ebetso ea pele ea lithethefatsi, e atisang ho bakoa ke ho khothaletsa phoofolo nakong ea phekolo ea makhetlo a mangata.

Ha ho sebetsana le lithethefatsi ena liphoofolong ho ka 'na ha hlokomeloa liphello tse chefo, letšollo, tachycardia, dermatitis, ho se utloe le ho se sebetse hantle ho tsamaisana.

Litšenyehelo le Tlhaloso

Litšenyehelo tsa moriana o potsoeng (1 g bottle) ke li-ruble tse 18.

Litsebi tse ling ha li ele hloko ho kopanya "Streptomycin Sulfate" le "Penicillin" ka sering e le 'ngoe. Leha ho le joalo, lingaka tse ling tsa katleho li sebelisa katleho ena ha ho phekoloa liphoofolo.

Batho ba kopaneng le lithethefatsi tsa bongaka ka nako e telele ba pheha khang ea hore ho ba le puisano e joalo hangata ho etsa hore ba hlahise dermatitis.

Ho ea ka litsebi, ho bolaoa ha liphoofolo tse neng li tsamaisoa "Streptomycin" ho lumelloa beke e le 'ngoe ka mor'a tšebeliso ea ho qetela ea lithethefatsi. Phoofolo ea liphoofolo e bolailoeng pele ho nako ea selemo e lokela ho sebelisoa bakeng sa tlhahiso ea phofo.

Mabapi le lebese, bakeng sa lijo li ka sebelisoa feela ka mor'a matsatsi a mabeli ka mor'a tsamaiso ea ho qetela ea lithethefatsi.