"Finoptinum": litaelo bakeng sa ho sebelisoa, sebopeho, counterparts ea sebele

Ho tsoa pelong 'me lefu le vascular ama batho ba bangata. Ho feta moo, ka lilemo, ba kotsing ea ho e re joalo lefu e ile ea eketseha haholo. Ho fokotsa kotsi ea dithulaganyo ka lintho tse tebileng 'meleng, lingaka khothalletsa tšebeliso ea lisebelisoa tsa khethehileng. Har'a bona ke haholo-holo e ratoang ke k'halsiamo le kanaleng blockers. Ba sehlopha heterogeneous ea lithethefatsi. mochine oa bona oa ketso e amanang le matla a ho thibela metsoako ea ho kenella ka hare tsa ions k'halsiamo ho tswa sebaka kantle ho sele ea lisele le methapo ea mali ea pelo. Fokotsa tsa mahloriso tsa likarolo tsena, moriana o fana ka vasodilating bohato.

Lithethefatsi atlehang ka ho fetisisa le thepa e joalo ke "finoptinum". Litaelo bakeng sa ho sebelisoa tsa sebopeho, analogs, ho bonahala hore li sebelisoe tsa lithethefatsi 'me liphello tsa eona tse lehlakoreng li hlalosoa o bitswang.

Foromo ya, sebopeho

Seo sebopeho ke bath ea lithethefatsi "finoptinum" joang? Litaelo ka kopo o re ho ka rekoa ka ente le lipilisi.

E le motsoako o mafolofolo moemeli ena nka khato verapamil hydrochloride. Hape le ka ho lokisetsa ho kenyeletsa dikgokelo tse fapa-fapaneng ba thusang (ho itšetlehile ka liforomo ho lokolloa).

litla diokobatsi

Ke lintho life tse sa tlholeho ka moriana "finoptinum"? Litaelo tsa tšebeliso, ulasan pelanggan ipolelang ke k'halsiamo le kanaleng blocker (khetha) sehlopha sa pele. Ke sehlahisoa difenilalkilamina le hlahisa antianginal, antihypertensive le bohato antiarrhythmic.

e le hantle Antianginal ea lithethefatsi ena e amanang le matla a ho ama myocardium le hemodynamics pheriferale. Ka mantsoe a mang, le lithethefatsi fokotsa molumo oa methapo. Ho phaella moo, ho fokotsa transformatsiiyu ATP matla ao e leng ka likamano tsa phahameng-eneji, le ka mosebetsi oa mechine le ho fokotsa myocardial contractility.

Hape re lokela ho ela hloko hore ho sebelisa lithethefatsi ena haholo ho fokotsa myocardial O2 le na le chronotropic mpe, inotropic le litla vasodilatory.

thepa ya moriana

Ka lebaka la ho sebopeho sa eona, le moriana o "finoptinum", analogues ya tse ho tse thathamisitsoeng ka tlaase mona, patelang batho ba automaticity tsa sinus noute fokotsa Av-conduction le eketsa nako refractory.

Eketsa makhetlo boikhathollo diastolic ventricle (ka ho le letšehali), lithethefatsi hona ho fokotsa tonus myocardial leboteng, i.e. ke ho bolela thusang ho phekola obstructive hypertrophic cardiomyopathy.

Ho lokela ho hlokomeloe hore ho nkoa moriana bontša thepa ea-ba khahlanong le arrhythmic le arrhythmias supraventricular.

The kinetics ya moriana

Ho lokisetsa "finoptinum" thuto eo ke e hlalositsoeng ka tlaase mona, e ananelang tswa pampitšana tshilong ya dijo (hoo e ka bang 90% ea lethal dose ea). mokgatlo lona le protheine e ke 90%.

moriana o metabolized temaneng ea (pele) ka sebete. Ena e bopa e sehlahisoa kang norverapamil hore ke ka tlaase ho moo hypotensive mosebetsi feta verapamil unmodified.

The halofo bophelo nakong ea lithethefatsi holim 'a amohela litekanyetso li behoa ea se nang molekane ke dihora tse 3-8. Ka ho sebelisoa ha tekanyetso khafetsa moriana o, palo ena fapana (lihora tse 5-12).

Nkiloeng lithethefatsi ka mala le liphio.

ya litatoli na

Maemong a mang, ho laela meriana "finoptinum"? Litaelo bakeng sa ho sebelisoa (matlapa le tharollo injectable na le e tšoanang showy) e bolela hore sesebelisoa sena ka sebelisoa bakeng sa ho supraventricular tachycardia (ho akarelletsa le paroxysmal, lefu Lown-Ganong-Levine le WPW-lefu), lichapo (gagamalo, tsitsitseng ntle vasoconstriction, tsitsitseng vasospastic), sinus tachycardia, atrial flutter, atrial tachyarrhythmia, atrial arrhythmia, hypertension bothata (bakeng sa tsamaiso intravenous), kgatelelo ya madi, bohlokwa kgatelelo ya madi ka hvs nyane ka ajoa, hypertrophic obstructive cardiomyopathy.

Contraindications

Ha se ho e laola "finoptinum"? Litaelo bakeng sa ho sebelisoa (liente le matlapa a na le contraindications tšoanang) e bontša hore thulusi ena e thibetsoe bakeng sa ho sebelisoa hypotension matla, sinoatrial thibella le kulang sinus syndrome, (ntle le ka bakuli ba sethusapelo a), Av-thibela likepe tsa boraro le la bobeli-lengolo la lefu Launa -Ganonga-Levin le WPW-lefu hammoho le fibrillation atrial kapa atrial flutter (ntle le batho ba kulang le sethusapelo a), boimana, hypersensitivity ho verapamil, kanyeso.

Lithethefatsi "finoptinum": litaelo tsa tšebeliso

The litekanyetso li behoa ea ea lithethefatsi e balwa ngaka le batho ka bomong.

bakuli ba batho ba baholo Letlapa o laolwa ka molomo ka lethal dose ea pele ea 40-80 mg, ka makhetlo a mararo ka letsatsi. Bakeng sa liforomo litekanyetso li behoa ka e le 'ngoe' matlafalitseng ho lokolloa litekanyetso li behoa lokela ho eketseha, 'me le maqhubu a ya tsamaiso - tlaase.

Bana ba lilemo li dilemo 6-14, meriana ena e kgothaletswa ho nka ka ka tjhelete e ya 80-360 mg, ka letsatsi, 'me ho fihlela ho lilemo tse 6 - ka lethal dose ea la 40-60 mg, ka ho ya ka letsatsi. The maqhubu a ya tsamaiso ya lithethefatsi ke ka makhetlo a mane ka letsatsi.

Haeba ho hlokahala, ea lithethefatsi potso ka laolwa entoe (butle). Kahoo ho hlokahala hore ho hlokomela ECG, khatello ea mali le ho otla ha pelo ea mokuli.

Lahloang tharollo litekanyetso li behoa bakeng sa batho ba baholo ke 5,10 mg,. Ha e le hantle phekolo e le sieo, metsotso e ka nako eo ka mor'a 20 ya ba lokisetsa ho ka boela a kena (ka lethal dose 'ngoe).

A le 'ngoe litekanyetso li behoa injectable foromo ea lithethefatsi bakeng sa bana lilemo tse 6-14 ba lilemong tsa ho 2.5-3.5 mg, bakeng sa bana ba lilemo tse 1-5 - 2-3, mg,' me bakeng sa ngoana ho fihlela ho selemo se le seng - 0.75-2 mg,.

Bakuli ba nang le tse matla sebete letsatsi lethal dose lokela ho sa feteng 120 mg,.

The litekanyetso li behoa palo e kahodimodimo ea ho lokisetsa molomo ka letsatsi ke 480 mg,.

litla-morao

Ho lokisetsa "finoptinum" ka qholotsa latelang liphetoho lehlakoreng:

• ho nona, bradycardia, agranulocytosis, kapa a ntseng a mpefala pelo hloleha, hyperprolactinemia, tachycardia, tahlehelo e fetang ea pono, edema pheriferale;
• tshwaileng e phokotso ea khatello ea mali, gynecomastia, galactorrhea, ramatiki, angina, arrhythmia, edema methapo, Av-ea le literata tsa lengolo la boraro, asystole, thrombocytopenia asymptomatic, putlama;
• ho nyekoa ke pelo, ho satalla ka matsoho kapa maoto, gingival hyperplasia, fainting, mokhathala, ho eketseha ha takatso ea lijo, ho tšoenyeha, ho eketseha ha transaminases sebete;
• letlalo lekhopho, ho tsekela, pipitlelano kapa letšollo, hlooho e opang, ho tepella maikutlo, robatseng, mafu extrapyramidal, mokhathala, Flushing ea letlalo, ke boroko, exudative etymology multiforme, pruritus.

ditshebeditsano lithethefatsi

Na hoa khoneha ho kopana le meriana e meng moriana "finoptinum"? Litaelo ka kōpo ea bolela hore ha e kopana le mahlahana tsena le lithethefatsi antihypertensive baa tiisa e le hantle bona antihypertensive.

Ke tsamaiso intravenous tsa verapamil ho batho ba sa tsoa o ile a fumana lethal dose ya beta-blockers, ho na le kotsi e khōlō ea hypotension (ea bohlokoa) le asystole.

Ha sebedisana laolwa "finoptinum" lithethefatsi le beta-blockers, meriana bakeng sa inhalation thethefatsa le lithethefatsi antiarrhythmic eketsa kotsi ea ho ba le pelo ea hloleha, bradycardia, hypotension matla le Av-thibela likepe.

Hammoho le kenoa "Amiodarone" Amplified bradycardia, mpe inotropic le hantle, Av-ea le literata le conduction meferefere.

Hobane verapamil thibela isozyme CYP3A4, amehang ka metabolism tsa simvastatin, lovastatin le atorvastatin ka 'na ba bang ba liponahatso sebelisana hore li bakoa ke ho eketseha concentrations tsa statins maling. maemo a ho rhabdomyolysis na hape.

thepa antianginal "finoptinum" Amplified ha ho kopantswe le nitrates.

Hammoho le tumello ya acid e acetylsalicylic e eketsehileng tsoa mali nakong e loketseng ho tseloe antiplatelet bohato.

Nka nka "Dizopiramid" hammoho le moriana "finoptinum"? Litaelo bakeng sa ho sebelisoa e tlaleha hore motswako ena ka 'na lebisa hypotension matla le putlama, haholo-holo batho ba nang le ho hloleha decompensated pelo kapa cardiomyopathy.

Ha u sebelisa matlapa bobeli le tharollo eketsa ea mahloriso tsa lona ka mali le "imipramine", eo ka eona kotsi ea liphetoho ho sa batleheng ka ECG. Ho lokela ho hlokomeloe hore verapamil eketsa bioavailability tsa "Imipramine", fokotsa rengwa lona.

Le ha e kopana le lithethefatsi le "carbamazepine" bohato ntlafatsoa tsa bobeli, hammoho le ho eketsa kotsi ea litla-morao ho tloha CNS.

Ka nako e tšoanang ho nka lithethefatsi le "clonidine" ho na le Maemong a tsa ho hloleha pelo ka batho ba nang le kgatelelo ya madi.

Ha kopantseng le moriana o le liponahatso lithium carbonate ea ditshebeditsano lithethefatsi ke tsejoa esale pele le e tsoakiloeng. Ho na le maemo a ho neurotoxicity, bradycardia matla, ntlafatsa liphello tsa lithium le phokotso ea mahloriso lona maling.

E le "Rifampicin 'liketso tse ka lithethefatsi" finoptinum "joang? e re Manual eo e kopana ena bitsang sebete enzyme, potlakisa mosebetsi oa ho metabolism tsa verapamil. Ena qetellong e isa ho fokotseha ha litleleniki tsa bohlokwa ba tsamaiso ya lithethefatsi ka eona.

likhothaletso itseng

Seo u lokelang ho se tseba pele ho sebelisa lithethefatsi "finoptinum" (40 mg,)? Tataiso e tlaleha hore thulusi ena e sebediswa ka hloko ha Av-thibela likepe tsa lengolo la pele, haholo aortic stenosis, bradycardia, myocardial infarction le ho ba teng ha ho hloleha letšehali ventricular, congestive pelo ho hloleha ho mofuta sa foleng, e leka-lekaneng kapa ea bonolo hypotension, e amanang le sebete kapa insufficiency renal. Hape ka hloko meriana ena e khothalletsoang hore ba hōlileng le bana.

Ka a hlobaetsang le ho hlokahale ho phethahatsoa ke motswako phekolo ea kgatelelo ya madi le angina ke verapamil le beta-blockers. Empa e ke ho hlokahala hore ho qoba tsamaiso intravenous ea bobeli.

Holim 'a baeti ba fihlelang ho ena ho bolela hore mamello e ka hlahisa liphetoho joalo motho eo, e le ho otsela kapa ho tsekela, e ka ama bokhoni ba motho a ho phetha mosebetsi oa kotsi.

Boimana le diabolololo

Hore na ho ka etsahala nakong e tlang-'mè le lecha tseo ke li behetsoeng lithethefatsi "finoptinum"? Litaelo bakeng sa ho sebelisoa nakong ea bokhachane na e le hore hona ho bolela hore le phello e bohloko ka ntshetsopeleng fetal. E boetse e fetelang ka lebese. Ka lebaka leo, tlas'a maemo ana a lithethefatsi e tieo contraindicated.

Moriana o "finoptinum": counterparts le theko

Theko oa sesebelisoa sena ka 'na ba e fapaneng. E le busa, ho itšetlehile ka mokgwa wa ho lokolloa ha lithethefatsi, palo lona kapa pharalla. Ka karolelano theko "finoptinum" ke 100-170 li-ruble.

Ha nkoa e le ea lithethefatsi o contraindicated, e ka nkeloa sebaka ke e 'ngoe ea ho bolela se latelang: "Verapamil", "Verogalid" "Verapamil-OBL", "Kaveri", "Verapamil Sopharma", "Verapamil-Lect," "Verapamil-Verein" "verapamil-ratiopharm" "Isoptin", "verapamil-Escom," "Vero verapamil," "verapamil hydrochloride" "Lekoptin".

Reviews of lingaka le bareki

Litsebi li bolela hore matlapa le tharollo "finoptinum" ke e atlehang le ho theko e tlaase ho bolela, tse etselitsoeng ho tsosolosa khatello ea mali, 'me ho ntlafatsa boiketlo ka mafu a tse ling tsa lijana pelo le mali.

Ha e le bakuli, boholo ba bona ba kgotsofala haholo ka liphello tsa kalafo le moemeli ena. Lipilisi kapa intravenous Infusion tharollo ntsetso-peleng felisoa e potlakileng ea matšoao a kgatelelo ya madi le lipontšo tse ling tsa lefu ea tsamaiso ea pelo le methapo.

Hape re lokela ho ela hloko hore ka lithethefatsi le ho fumana litlaleho tse mpe. Ba bua ka palo e khōlō ea liphetoho lehlakoreng tse etsahalang hang-hang ka mor'a ho sebelisa lithethefatsi. Hape, basebelisi ba bangata ba tletleba ka contraindications ho a mangata.